Methylthiophosphonsaeure-hexylester | 20541-01-9

• 分子结构分类: 有机化合物 - 有机磷化合物 - 有机硫代磷化合物
• 英文名称: Methylthiophosphonsaeure-hexylester
• 英文别名: hexoxy-hydroxy-methyl-sulfanylidene-λ5-phosphane
• CAS: 20541-01-9
• 化学式: C₇H₁₇O₂PS
• 分子量: 196.251
• InChiKey: SCUSRQXSCRLORG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  61.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  甲基亚膦酸己酯 在 sulfur 作用下， 以 1,4-二氧六环 为溶剂， 生成 Methylthiophosphonsaeure-hexylester
  参考文献：
  名称：

  Petrov,K.A. et al., Journal of general chemistry of the USSR, 1961, vol. 31, p. 168 - 171

  摘要：

  DOI：

文献信息

• NUCLEIC ACID, COMPOSITION AND CONJUGATE CONTAINING SAME, AND PREPARATION METHOD AND USE
  申请人：Suzhou Ribo Life Science Co., Ltd.

  公开号：EP3719125A1

  公开（公告）日：2020-10-07

  Provided are a siRNA for inhibiting the expression of hepatitis B virus gene, and a pharmaceutical composition and conjugate containing the siRNA. Each nucleotide in the siRNA is independently a modified nucleotide. The siRNA comprises a sense strand and an antisense strand. The sense strand of the siRNA comprises a nucleotide sequence 1 having the same length and no more than three nucleotides different from the nucleotide sequence shown in SEQ ID NO: 155, and the antisense strand of the siRNA comprises a nucleotide sequence 2 having the same length and no more than three nucleotides different from the nucleotide sequence shown in SEQ ID NO: 156.

  本文提供了一种用于抑制乙型肝炎病毒基因表达的 siRNA，以及含有该 siRNA 的药物组合物和共轭物。 siRNA 中的每个核苷酸都是独立的修饰核苷酸。 siRNA 包括有义链和反义链。 siRNA 的有义链包括与 SEQ ID NO: 155 所示核苷酸序列具有相同长度且相差不超过三个核苷酸的核苷酸序列 1，而 siRNA 的无义链包括与 SEQ ID NO: 156 所示核苷酸序列具有相同长度且相差不超过三个核苷酸的核苷酸序列 2。
• NUCLEIC ACID, COMPOSITION AND CONJUGATE CONTAINING NUCLEIC ACID, PREPARATION METHOD AND USE
  申请人：Suzhou Ribo Life Science Co., Ltd.

  公开号：EP3718572A1

  公开（公告）日：2020-10-07

  Provided are an siRNA for inhibiting expression of a Hepatitis B virus gene, and a pharmaceutical composition and conjugate containing the siRNA. Each nucleotide in the siRNA is an independently modified or unmodified nucleotide; the siRNA comprises a sense strand and an antisense strand; the sense strand comprises a nucleotide sequence A; the length of the nucleotide sequence A is the same as that of a nucleotide sequence as shown in SEQ ID NO: 1, and the number of the nucleotide differences is not more than three; the antisense strand comprises a nucleotide sequence B; and the length of the nucleotide sequence B is the same as that of a nucleotide sequence as shown in SEQ ID NO: 2, and number of nucleotide differences is not more than three.

  本发明提供了一种用于抑制乙型肝炎病毒基因表达的 siRNA，以及含有该 siRNA 的药物组合物和共轭物。siRNA 中的每个核苷酸都是独立修饰或未修饰的核苷酸；siRNA 包括有义链和反义链；有义链包括核苷酸序列 A；核苷酸序列 A 的长度与 SEQ ID NO：1 所示的核苷酸序列相同，且核苷酸差异数目不超过三个；反义链包括核苷酸序列 B；核苷酸序列 B 的长度与 SEQ ID NO: 2 所示的核苷酸序列相同，且核苷酸差异数目不超过三个。
• Synthesis, reaction with esterases, and toxicity of O-alkyl S-(carbalkoxymethylmercapto)methyl methylthiophosphonates
  作者：T. A. Mastryukova、A. �. Shipov、Z. K. Emkuzheva、A. P. Brestkin、I. L. Brik、Yu. E. Mandel'shtam、A. N. Fedin、T. I. Nozhko、Z. Tilyabaev、S. A. Roslavtseva、Yu. S. Kagan、E. A. Ershova、M. I. Kabachnik

  DOI：10.1007/bf00949696

  日期：1980.5
• Petrov,K.A. et al., Journal of general chemistry of the USSR, 1961, vol. 31, p. 168 - 171
  作者：Petrov,K.A. et al.

  DOI：——

  日期：——