azulene-1-carbanilide | 30575-44-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: azulene-1-carbanilide
• 英文别名: N-Phenyl-azulen-1-carbamid；Azulen-1-carbanilid；Azulen-1-carbonsaeure-anilid；N-phenylazulene-1-carboxamide
• CAS: 30575-44-1
• 化学式: C₁₇H₁₃NO
• 分子量: 247.296
• InChiKey: MYSYWRKUQDOSAV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  光气 、 奥苷菊环 在 甲苯 作用下， 生成 azulene-1-carbanilide
  参考文献：
  名称：

  Treibs et al., Chemische Berichte, 1959, vol. 92, p. 1216,1221

  摘要：

  DOI：

文献信息

• Abe, Noritaka; Chijimatsu, Hiroshi; Kondo, Satoru, Journal of Chemical Research, Miniprint, 1997, # 11, p. 2434 - 2458
  作者：Abe, Noritaka、Chijimatsu, Hiroshi、Kondo, Satoru、Watanabe, Hiroyuki、Saito, Katsuhiro

  DOI：——

  日期：——
• SUBSTITUTED FUSED PYRAZOLECARBOXYLIC ACID ARYLAMIDES AND RELATED COMPOUNDS
  申请人：Neurogen Corporation

  公开号：EP1472252A1

  公开（公告）日：2004-11-03
• [EN] SUBSTITUTED FUSED PYRAZOLECARBOXYLIC ACID ARYLAMIDES AND RELATED COMPOUNDS<br/>[FR] ARYLAMIDES D'ACIDE PYRAZOLECARBOXYLIQUE SUBSTITUES, FUSIONNES, ET COMPOSES ASSOCIES
  申请人：NEUROGEN CORP

  公开号：WO2003066634A1

  公开（公告）日：2003-08-14

  Heterocyclic compounds such as 3,4,5,6-tetrahydro-2,3,10-triaza-benzo[e]azulene-1-carboxylic acid arylamides, 5,7-Dihydro-6H-pyrazolo[3,4-h]quinoline-9-carboxylic acid arylamides, 5,7-Dihydro-6H-pyrazolo[3,4-h]quinazoline-9-carboxylic acid arylamides, 2,4,5,6-Tetrahydro-1,2,6,7-tetraaza-as-indacene-8-carboxylic acid arylamides and related compounds are disclosed. These compounds are highly selective agonists, antagonists or inverse agonists for GABAA brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAA brain receptors and are therefore useful in the treatment of anxiety, depression, sleep and seizure disorders, overdose with benzodiazepine drugs, Alzheimer's dementia, and for enhancement of memory. Pharmaceutical compositions, including packaged pharmaceutical compositions, are further provided. Intermediates useful for the synthesis of pyrazolecarboxylic acid arylamides are also provided. Compounds of the invention are also useful as probes for the localization of GABAA receptors in tissue samples.
• Treibs et al., Chemische Berichte, 1959, vol. 92, p. 1216,1221
  作者：Treibs et al.

  DOI：——

  日期：——