1-[(2R)-4-azido-5-(methoxymethyl)oxolan-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione | 121456-54-0

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 1-[(2R)-4-azido-5-(methoxymethyl)oxolan-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
• 英文别名: kamuvudine 5；3'-Azido-5'-O-methyl-3'-deoxythymidine；1-[(2R,4S,5S)-4-azido-5-(methoxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
• CAS: 121456-54-0
• 化学式: C₁₁H₁₅N₅O₄
• 分子量: 281.271
• InChiKey: GFZQAQHNKSAIDN-DJLDLDEBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  82.2
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• COMPOSITIONS AND METHODS FOR TREATING RETINAL DEGRADATION
  申请人：University of Kentucky Research Foundation

  公开号：US20150038446A1

  公开（公告）日：2015-02-05

  The present disclosure relates to compositions and methods for treating retinal damage and/or retinal degradation. More specifically, this disclosure relates to methods for treating degradation of the retinal pigment epithelium by administering compositions comprising a nucleoside and/or a nucleoside or nucleotide reverse transcriptase inhibitor.
• US9326983B2
  申请人：——

  公开号：US9326983B2

  公开（公告）日：2016-05-03