3-((3,5-Dimethoxyphenyl)amino)-2-hydroxypropane-1-sulfonic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-((3,5-Dimethoxyphenyl)amino)-2-hydroxypropane-1-sulfonic acid
• 英文别名: 3-(3,5-dimethoxyanilino)-2-hydroxypropane-1-sulfonic acid
• 化学式: C₁₁H₁₇NO₆S
• 分子量: 291.32
• InChiKey: AOTXQRRUWFSXCN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  114
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• [EN] METHODS FOR THE TREATMENT OF CARDIOVASCULAR DISORDERS<br/>[FR] PROCÉDÉS POUR LE TRAITEMENT DE TROUBLES CARDIOVASCULAIRES
  申请人：GALAPAGOS NV

  公开号：WO2016165952A1

  公开（公告）日：2016-10-20

  The present invention discloses compounds according to Formula (I): or a pharmaceutically acceptable salt thereof, or a solvate or the salt of a solvate thereof, pharmaceutical compositions comprising the same, and methods of treatment using the same, for use in the prophylaxis and/or treatment of cardiovascular disorders and/or dyslipidemia, by administering the compound according to Formula (I).

  本发明公开了按照公式（I）的化合物：或其药学上可接受的盐，或其溶剂或其溶剂的盐，包括它们的药物组成物，以及使用该化合物的治疗方法，用于预防和/或治疗心血管疾病和/或血脂异常，通过给予公式（I）的化合物。
• Determination method of biological component and reagent kit used therefor
  申请人：——

  公开号：US20020119507A1

  公开（公告）日：2002-08-29

  The present invention provides novel glutathione-dependent formaldehyde dehydrogenase that makes possible quantitative measurement of formaldehyde by cycling reaction, and a determination method of formaldehyde and biological components, such as creatinine, creatine, homocysteine and the like, which produces formaldehyde as a reaction intermediate. In addition, the present invention provides a reagent kit for the above-mentioned determination method. The present invention provides a novel determination method of a homocysteine using transferase utilizing homocysteine and other compound as a pair of substrates. Particularly, the present invention provides a determination method of homocysteine which includes bringing betaine-homocysteine methyltransferase and dimethylglycine oxidase into contact with a sample and measuring produced hydrogen peroxide or formaldehyde. Moreover, the present invention provides novel dimethylglycine oxidase stable to thiol compound, which is suitably used for the measurement. The present invention provides a reagent kit used for any of the above-mentioned determination methods of homocysteines.

  本发明提供了一种新型的谷胱甘肽依赖性甲醛脱氢酶，它使得通过循环反应定量测量甲醛成为可能，并提供了一种测定甲醛和生物成分（如肌酐、肌酸、同型半胱氨酸等）的方法，该方法产生甲醛作为反应中间体。此外，本发明还提供了用于上述测定方法的试剂盒。本发明提供了一种新型的利用同型半胱氨酸和其他化合物作为一对底物的转移酶测定同型半胱氨酸的方法。特别是，本发明提供了一种同型半胱氨酸的测定方法，其中包括将甜菜碱-同型半胱氨酸甲基转移酶和二甲基甘氨酸氧化酶与样品接触，并测量产生的过氧化氢或甲醛。此外，本发明还提供了一种对巯基化合物稳定的新型二甲基甘氨酸氧化酶，适用于测量。本发明提供了用于上述同型半胱氨酸测定方法的试剂盒。
• METHOD FOR MEASURING TRIGLYCERIDE IN LOW-DENSITY LIPOPROTEIN AND KIT FOR MEASUREMENT
  申请人：Katayama Yuki

  公开号：US20090226944A1

  公开（公告）日：2009-09-10

  The present invention provides a method for a simple and accurate measurement of triglycerides in low-density lipoprotein in a sample comprising performing the following steps sequentially: (i) a step of generating free glycerol by allowing lipoprotein lipase to act on a sample, in an aqueous medium comprising the sample and a specific surfactant such as polyoxyethylene polyoxyalkylene polycyclic phenyl ether; (ii) a step of removing free glycerol present in the reaction solution of the above step (i); (iii) a step of generating free glycerol by allowing lipoprotein lipase to act on the reaction solution from which free glycerol has been removed in step (ii), in the presence of a specific surfactant such as polyoxyethylene polyoxyalkylene alkyl ether; and (iv) a step of measuring free glycerol generated in step (iii), and a kit used for the method.

  本发明提供了一种简单准确地测量样品中低密度脂蛋白中甘油三酯的方法，包括按照以下步骤顺序进行：(i)在包括样品和特定表面活性剂（例如聚氧乙烯聚氧烷基多环苯醚）的水介质中，使脂蛋白酯酶作用于样品，生成游离甘油；(ii)去除步骤(i)中反应溶液中存在的游离甘油；(iii)在去除步骤(ii)中的游离甘油的反应溶液中，使脂蛋白酯酶作用于特定表面活性剂（例如聚氧乙烯聚氧烷基烷基醚）的存在下，生成游离甘油；(iv)测量步骤(iii)中生成的游离甘油，以及用于该方法的试剂盒。
• OXIDATIVE CHROMOGENIC COMPOUND OR SALT THEREOF AND PRODUCTION METHOD THEREOF, AND REAGENT COMPOSITION AND TEST INSTRUMENT USING THE SAME
  申请人：Kawanishi Tetsuro

  公开号：US20100062464A1

  公开（公告）日：2010-03-11

  It is an object of the present invention to provide a means for measuring a concentration of various components rapidly with high accuracy and high sensitivity. The present invention is to provide an oxidative chromogenic compound or salt thereof represented by the following chemical formula (1): wherein R 1 and R 2 are each independently a linear or branched alkyl group having 1 to 5 carbon atoms; R 3 , R 4 , R 5 , R 6 and R 7 are each independently a hydrogen atom, a carboxyl group or a sulfonic acid group, or salt thereof, provided that at least one of R 3 to R 7 is a carboxyl group or a sulfonic acid group, or salt thereof, and the others are hydrogen atoms, and the production method thereof, and the reagent composition and test instrument using the same.

  本发明的目的是提供一种快速、高精度和高灵敏度测量各种成分浓度的手段。本发明提供了一种氧化性显色化合物或其盐，其化学式如下（1）：其中R1和R2分别是具有1至5个碳原子的线性或支链烷基；R3、R4、R5、R6和R7分别是氢原子、羧基或磺酸基，或其盐，但至少其中之一是羧基或磺酸基，或其盐，其余为氢原子，以及其生产方法、试剂组成和使用该试剂组成的测试仪器。
• Novel pyranose oxidase processes for the production and use thereof and test compositions for use therein
  申请人：KYOWA HAKKO KOGYO CO., LTD.

  公开号：EP0119332A1

  公开（公告）日：1984-09-26

  A novel pyranose oxidase exhibiting strong specific activity substantially only on glucose is disclosed, as well as a method for its preparation by fermentation of a microorganism of the genus Coriolus, Daedaleopsis, Gloeophyllum or Pleurotus. The enzyme is useful for the determination of glucose, and methods for doing this, as well as components for use therein are described.

  本论文公开了一种新型吡喃糖氧化酶，该酶基本上只对葡萄糖具有很强的特异性活性，还公开了一种通过科里奥利斯属、Daedaleopsis 属、Gloeophyllum 属或 Pleurotus 属微生物发酵制备该酶的方法。 该酶可用于葡萄糖的测定，并介绍了测定方法及其使用的成分。