Acetohydrazide; pyridine | 7467-32-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: Acetohydrazide; pyridine
• 英文别名: acetohydrazide;pyridine
• CAS: 7467-32-5
• 化学式: C7H11N3O
• 分子量: 153.18
• InChiKey: ADTNAQKEGWXKCL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.08
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  68
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Acetohydrazide; pyridine 、 联苯单乙酮 生成 N-[(E)-1-(4-phenylphenyl)ethylideneamino]acetamide;pyridine
  参考文献：
  名称：

  CHIHARA, TEIJI;WANIGUCHI, ERIKA;WAKABAYASHI, TAMIE;TAYA, KAZUO, CHEM. LETT., 1983, N 10, 1647-1648

  摘要：

  DOI：
• 作为产物：
  描述：

  N-[(E)-1-(4-phenylphenyl)ethylideneamino]acetamide;pyridine 、 盐酸 生成 Acetohydrazide; pyridine
  参考文献：
  名称：

  CHIHARA, TEIJI;WANIGUCHI, ERIKA;WAKABAYASHI, TAMIE;TAYA, KAZUO, CHEM. LETT., 1983, N 10, 1647-1648

  摘要：

  DOI：

文献信息

• 7-Substituted camptothecin derivatives and process for their preparation
  申请人：KABUSHIKI KAISHA YAKULT HONSHA

  公开号：EP0056692A1

  公开（公告）日：1982-07-28

  7-substituted camptothecin derivatives of the general formula wherein R represents-CHO,-CH2OR',-CH(OR')2 or-CH=N-X where R' is a lower alkyl group having from 1 to 6 carbon atoms or a phenylalkyl group having from 1 to 3 carbon atoms in the alkylene moiety thereof, and X is a hydroxyl group or -NR1R2 where R1 and R are the same or different and each represent hydrogen atom or a lower alkyl group having from 1 to 6 carbon atoms, or when R' is hydrogen, R2 may be a lower alkyl group having from 1 to 6 carbon atoms, a substituted or unsubstituted aryl group, a carbamoyl group, an acyl group, an aminoalkyl group or an amidino group, or when R' is a lower alkyl group, R2 may be an aminoalkyl group, or R1 and R2 may be combined together with the nitrogen atom to which they are attached to form a heterocyclic group which may be interrupted by one or two nitrogen, oxygen and/or sulfur atoms, and the quaternary salts thereof.

  通式为 7-取代的喜树碱衍生物 其中 R 代表-CHO、-CH2OR'、-CH(OR')2 或-CH=N-X 其中 R'是具有 1 至 6 个碳原子的低级烷基或在其亚烷基中具有 1 至 3 个碳原子的苯基烷基，X 是羟基或-NR1R2 其中 R1 和 R 相同或不同，各自代表氢原子或具有 1 至 6 个碳原子的低级烷基，或当 R' 是氢时，R2 可以是具有 1 至 6 个碳原子的低级烷基、取代或未取代的芳基、氨基甲酰基、酰基、氨基烷基或脒基，或当 R' 为低级烷基时，R2 可为氨基烷基，或 R1 和 R2 可与所连接的氮原子结合在一起，形成可被一个或两个氮、氧和/或硫原子间断的杂环基团及其季盐。
• 1-H-Indole-2,3-dione derivatives and preparation thereof
  申请人：STERLING DRUG INC.

  公开号：EP0089394A1

  公开（公告）日：1983-09-28

  1-R,-4- or 5-[4-pyridinyl-(CH2)n]-1H-indole-2,3-dione 3-Q derivatives, useful as cardiotonics, bronchodilators, anti-asthmatics, anti-allergics and anti-cholinergics, are prepared by cyclization of an N-3- or 4-[4-pyridinyl(CH2)n]phenyl}- glyoxalamide oxime with acid; reaction of the product thus obtained with a carbonyl reactive reagent to prepare a compound where Q is other than 0; and reaction of a compound where 0 is either O or other than O with a lower-alkyl, hydroxy-lower-alkyl or di-lower-alkylamino-lower-alkyl ester of a strong mineral acid or with a carbo-lower-alkoxy-lower-alkyl halide to prepare compounds where R, is other than hydrogen.

  1-R,-4-或 5-[4-吡啶基-(CH2)n]-1H-吲哚-2,3-二酮 3-Q 衍生物，可用作强心剂、支气管扩张剂、抗哮喘药、抗过敏药和抗胆碱药，其制备方法是：将 N-3-或 4-[4-吡啶基( )n]苯基}-乙二醛酰胺肟与酸环化；将由此得到的产物与羰基反应试剂反应，制备 Q 为 0 以外的化合物；将 0 为 O 或 O 以外的化合物与强矿物酸的低级烷基、羟基低级烷基或二低级烷基氨基低级烷基酯或羧基低级烷氧基低级烷基卤化物反应，制备 R 为氢以外的化合物。
• Chemical synthesis method of Plesiomonas shigelloides serotype O51 O-antigen oligosaccharide
  申请人：Jiangnan University

  公开号：US10851130B2

  公开（公告）日：2020-12-01

  The present disclosure discloses the chemical synthesis method of the Plesiomonas shigelloides serotype O51 O-antigen oligosaccharide, belonging to the field of chemistry. Source-abundant D-glucose, L-fucose, D-glucosamine and the like are used as raw materials to prepare three glycosylation building blocks, the synthetic route composed of 11 reaction modules is designed, and through the optimization of protecting group and the optimization of the time of introducing functional group, the preparation of the target oligosaccharide chain is successfully achieved. The oligosaccharide chain prepared in the present disclosure has the advantages of cheap and easy-to-get raw materials, and simple and easy-to-repeat preparation method. The present disclosure will have good application prospects in the aspects of development of new drugs and vaccines of Plesiomonas shigelloides, and the like.

  本发明公开了一种 "屎壳郎单胞菌血清型O51 O-抗原寡糖 "的化学合成方法，属于化学领域。以来源丰富的D-葡萄糖、L-岩藻糖和D-氨基葡萄糖等为原料，制备三个糖基化构筑物，设计了由11个反应模块组成的合成路线，通过保护基团的优化和官能团引入时间的优化，成功制备了目标寡糖链。本发明制备的寡糖链具有原料廉价易得、制备方法简单易重复等优点。本公开的内容在灰葡萄孢单胞菌新药和疫苗的开发等方面具有良好的应用前景。
• Chemical Synthesis Method of Plesiomonas Shigelloides Serotype O51 O-antigen Oligosaccharide
  申请人：Jiangnan University

  公开号：US20190233459A1

  公开（公告）日：2019-08-01

  The present disclosure discloses the chemical synthesis method of the Plesiomonas shigelloides serotype O51 O-antigen oligosaccharide, belonging to the field of chemistry. Source-abundant D-glucose, L-fucose, D-glucosamine and the like are used as raw materials to prepare three glycosylation building blocks, the synthetic route composed of 11 reaction modules is designed, and through the optimization of protecting group and the optimization of the time of introducing functional group, the preparation of the target oligosaccharide chain is successfully achieved. The oligosaccharide chain prepared in the present disclosure has the advantages of cheap and easy-to-get raw materials, and simple and easy-to-repeat preparation method. The present disclosure will have good application prospects in the aspects of development of new drugs and vaccines of Plesiomonas shigelloides , and the like.
• US4322533A
  申请人：——

  公开号：US4322533A

  公开（公告）日：1982-03-30