methyl 7-benzyl-4-hydroxy-5,6,7,8-tetrahydro-1,7-naphthyridine-3-carboxylate | 911010-89-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: methyl 7-benzyl-4-hydroxy-5,6,7,8-tetrahydro-1,7-naphthyridine-3-carboxylate
• 英文别名: 7-benzyl-4-hydroxy-5,6,7,8-tetrahydro-[1,7]naphthyridine-3-carboxylic acid methyl ester；methyl 7-benzyl-4-oxo-1,5,6,8-tetrahydro-1,7-naphthyridine-3-carboxylate
• CAS: 911010-89-4
• 化学式: C₁₇H₁₈N₂O₃
• 分子量: 298.342
• InChiKey: NKRRJUVJURBTAJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  58.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  methyl 7-benzyl-4-hydroxy-5,6,7,8-tetrahydro-1,7-naphthyridine-3-carboxylate 在 三氯氧磷 作用下， 反应 5.0h， 生成 methyl 7-benzyl-4-chloro-5,6,7,8-tetrahvdro-1,7-naphthyridine-3-carboxylate
  参考文献：
  名称：

  [EN] TRKA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
  [FR] INHIBITEURS DE LA KINASE TRKA, COMPOSITIONS EN CONTENANT ET MÉTHODES ASSOCIÉES

  摘要：

  公开号：

  WO2015148344A3
• 作为产物：
  描述：

  1-苄基-3-氧杂-4-哌啶甲酸乙酯 在 potassium tert-butylate 、 ammonium acetate 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 36.0h， 生成 methyl 7-benzyl-4-hydroxy-5,6,7,8-tetrahydro-1,7-naphthyridine-3-carboxylate
  参考文献：
  名称：

  [EN] TRKA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
  [FR] INHIBITEURS DE LA KINASE TRKA, COMPOSITIONS EN CONTENANT ET MÉTHODES ASSOCIÉES

  摘要：

  公开号：

  WO2015148344A3

文献信息

• SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF
  申请人：Blackburn Christopher

  公开号：US20120053201A1

  公开（公告）日：2012-03-01

  This invention provides compounds of formula (I): wherein R 1a , R 1b , R 1c , R 1d , R 2a , R 2b , X 1 , X 2 , and G have values as described in the specification, useful as inhibitors of HDAC6. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative, inflammatory, infectious, neurological or cardiovascular diseases or disorders.

  这项发明提供了式（I）的化合物： 其中R1a、R1b、R1c、R1d、R2a、R2b、X1、X2和G的取值如规范中所述，可用作HDAC6的抑制剂。该发明还提供了包括该发明化合物的药物组合物，以及在治疗增殖性、炎症性、感染性、神经系统或心血管疾病或紊乱中使用这些组合物的方法。
• Bicycloheteroaryl compounds as P2X7 modulators and uses thereof
  申请人：Kelly G. Michael

  公开号：US20060217448A1

  公开（公告）日：2006-09-28

  Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

  公开了具有以下公式代表的Bicycloheteroaryl化合物：这些化合物可以制备为药物组合物，并可用于预防和治疗包括人类在内的哺乳动物的各种疾病，例如疼痛、炎症、创伤性损伤等。
• Bicycloheteroaryl Compounds as P2X7 Modulators and Uses Thereof
  申请人：Kelly G Michael

  公开号：US20080039478A1

  公开（公告）日：2008-02-14

  Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

  本文披露了一种具有以下公式表示的Bicycloheteroaryl化合物：这些化合物可以制备为药物组成物，并可用于预防和治疗哺乳动物包括人类的各种疾病，包括但不限于疼痛，炎症，创伤性损伤等。
• Bicycloheteroaryl compounds as P2X7 modulators and uses thereof
  申请人：Renovis, Inc.

  公开号：US07297700B2

  公开（公告）日：2007-11-20

  Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

  公开了具有以下表示式的双环杂环芳基化合物：这些化合物可以制备为药物组合物，并可用于预防和治疗哺乳动物，包括人类的各种疾病，例如疼痛，炎症，创伤性损伤等。
• BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF
  申请人：Renovis, Inc.

  公开号：EP1860942A2

  公开（公告）日：2007-12-05