2-cyano-3-(2,3,4-trifluorophenyl)aminoacrylic acid ethyl ester | 144367-60-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-cyano-3-(2,3,4-trifluorophenyl)aminoacrylic acid ethyl ester
• 英文别名: Ethyl 2-cyano-3-(2,3,4-trifluoroanilino)prop-2-enoate
• CAS: 144367-60-2
• 化学式: C₁₂H₉F₃N₂O₂
• mdl: MFCD12197265
• 分子量: 270.211
• InChiKey: JISHJNKMEZITCN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.166
• 拓扑面积：
  62.1
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2-cyano-3-(2,3,4-trifluorophenyl)aminoacrylic acid ethyl ester 以 二苯醚 为溶剂， 反应 0.33h， 以74.2%的产率得到6,7,8-三氟-4-羰基-1H-喹啉-3-甲腈
  参考文献：
  名称：

  Microwave-Assisted Simple Synthesis of Substituted 4-Quinolone Derivatives

  摘要：

  A simple and efficient method was developed for the synthesis of 4-quinolone-3-carboxylic esters and 4-quinolone-3-carbonitriles under microwave (MW) activation using anilines and acrylates as materials. All reactions demonstrated the benefits of microwave reactions: convenient operation, short reaction time, and good yields.

  DOI：

  10.1080/00397910902906503
• 作为产物：
  描述：

  2,3,4-三氟苯胺 、 2-氰基-3-乙氧基丙烯酸乙酯 生成 2-cyano-3-(2,3,4-trifluorophenyl)aminoacrylic acid ethyl ester
  参考文献：
  名称：

  Microwave-Assisted Simple Synthesis of Substituted 4-Quinolone Derivatives

  摘要：

  A simple and efficient method was developed for the synthesis of 4-quinolone-3-carboxylic esters and 4-quinolone-3-carbonitriles under microwave (MW) activation using anilines and acrylates as materials. All reactions demonstrated the benefits of microwave reactions: convenient operation, short reaction time, and good yields.

  DOI：

  10.1080/00397910902906503

文献信息

• Microwave-Assisted Simple Synthesis of Substituted 4-Quinolone Derivatives
  作者：Xin Cao、Qi-Dong You、Zhi-Yu Li、Yan Yang、Xiao-Jian Wang

  DOI：10.1080/00397910902906503

  日期：2009.11.18

  A simple and efficient method was developed for the synthesis of 4-quinolone-3-carboxylic esters and 4-quinolone-3-carbonitriles under microwave (MW) activation using anilines and acrylates as materials. All reactions demonstrated the benefits of microwave reactions: convenient operation, short reaction time, and good yields.