5-(4-methoxyphenyl)-2-thioxo-5-p-tolylimidazolidin-4-one | 1028432-48-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-(4-methoxyphenyl)-2-thioxo-5-p-tolylimidazolidin-4-one
• 英文别名: 5-(4-Methoxyphenyl)-5-(4-methylphenyl)-2-sulfanylideneimidazolidin-4-one；5-(4-methoxyphenyl)-5-(4-methylphenyl)-2-sulfanylideneimidazolidin-4-one
• CAS: 1028432-48-5
• 化学式: C₁₇H₁₆N₂O₂S
• 分子量: 312.392
• InChiKey: PMWZLUZXVOZBJQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  82.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-(4-甲氧基-苯基)-2-对甲苯基-乙烷-1,2-二酮 、 硫脲 在 氢氧化钾 作用下， 反应 1.0h， 生成 5-(4-methoxyphenyl)-2-thioxo-5-p-tolylimidazolidin-4-one
  参考文献：
  名称：

  DMSO–PdI2 as a powerful oxidizing couple of alkynes into benzils: one-pot synthesis of nitrogen-containing five- or six-membered heterocycles

  摘要：

  PdI2 in DMSO promoted the oxidation of functionalized diarylalkynes into benzil derivatives in excellent yields. This new oxidation reaction was achieved with short reaction times and low loading of palladium catalyst. This efficient catalytic process has been applied successfully to the one-pot construction of a series of nitrogen-containing heterocycles of biological interest according to a tandem oxidation-nitrogen nucleophiles condensation-cyclization. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.02.081

文献信息

• DMSO–PdI2 as a powerful oxidizing couple of alkynes into benzils: one-pot synthesis of nitrogen-containing five- or six-membered heterocycles
  作者：Céline Mousset、Olivier Provot、Abdallah Hamze、Jérôme Bignon、Jean-Daniel Brion、Mouâd Alami

  DOI：10.1016/j.tet.2008.02.081

  日期：2008.5

  PdI2 in DMSO promoted the oxidation of functionalized diarylalkynes into benzil derivatives in excellent yields. This new oxidation reaction was achieved with short reaction times and low loading of palladium catalyst. This efficient catalytic process has been applied successfully to the one-pot construction of a series of nitrogen-containing heterocycles of biological interest according to a tandem oxidation-nitrogen nucleophiles condensation-cyclization. (c) 2008 Elsevier Ltd. All rights reserved.