N,N'-((5,6-dicyanopyrazine-2,3-diyl)bis(methylene))bis(N-phenylacetamide) | 142312-11-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N'-((5,6-dicyanopyrazine-2,3-diyl)bis(methylene))bis(N-phenylacetamide)
• 英文别名: N-{3-[(Acetyl-phenyl-amino)-methyl]-5,6-dicyano-pyrazin-2-ylmethyl}-N-phenyl-acetamide
• CAS: 142312-11-6
• 化学式: C₂₄H₂₀N₆O₂
• 分子量: 424.462
• InChiKey: PLUUIXLYSCMRMJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.33
• 重原子数：
  32.0
• 可旋转键数：
  6.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  113.98
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为产物：
  描述：

  2,3-二氰基吡嗪 、 N-乙酰-N-苯基甘氨酸 在 ammonium persulfate 、 silver nitrate 作用下， 以 水 、 乙腈 为溶剂， 反应 0.67h， 以30%的产率得到5-(N-acetylanilino)methylpyrazine-2,3-dicarbonitrile
  参考文献：
  名称：

  Amidoalkylation of Pyrazine-2,3-dicarbonitrile by the Radical Generated from N-Alkanoylanilinoalkanoic Acid

  摘要：

  N-Alkanoylanilinoacetic acid and 2-N-alkanoylanilinopropionic acid gave N-alkanoylanilinomethyl radical and 1-N-alkanoylanilinoethyl radical respectively by the peroxodisulfate oxidation catalized by silver ion. The former radical reacts with pyrazine-2,3-dicarbonitrile to give both monosubstitution product (6) and disubstitution product (7), whereas the latter radical gives only monosubstitution product due to the steric hindrance for the second radical substitution.

  DOI：

  10.3987/com-91-5931

文献信息

• Amidoalkylation of Pyrazine-2,3-dicarbonitrile by the Radical Generated from N-Alkanoylanilinoalkanoic Acid
  作者：Masaru Tada、Reiko Furuse、Hiroko Kashima

  DOI：10.3987/com-91-5931

  日期：——

  N-Alkanoylanilinoacetic acid and 2-N-alkanoylanilinopropionic acid gave N-alkanoylanilinomethyl radical and 1-N-alkanoylanilinoethyl radical respectively by the peroxodisulfate oxidation catalized by silver ion. The former radical reacts with pyrazine-2,3-dicarbonitrile to give both monosubstitution product (6) and disubstitution product (7), whereas the latter radical gives only monosubstitution product due to the steric hindrance for the second radical substitution.