(2-(3-dimethylamino-propylamino)-1,4-dihydroxy-anthraquinone) | 3900-43-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: (2-(3-dimethylamino-propylamino)-1,4-dihydroxy-anthraquinone)
• 英文别名: 2-[3-(Dimethylamino)propylamino]-1,4-dihydroxyanthracene-9,10-dione
• CAS: 3900-43-4
• 化学式: C₁₉H₂₀N₂O₄
• 分子量: 340.379
• InChiKey: PCIUVTQUMJMKAU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  89.9
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Protein tyrosine phosphatase-prl-1 a a marker and therapeutic target for pancreatic cancer
  申请人：Farnsworth L Amanda

  公开号：US20070026398A1

  公开（公告）日：2007-02-01

  Using gene expression profiling, the present Invention identifies Protein tyrosine phosphatase IVA member 1 (PRL-1) as a diagnostic marker and therapeutic target for pancreatic cancer. The Invention therefore provides methods for prediction and detection of PRL-1 associated cancers, and evaluation of inhibitors of PRL-1. The Invention also provides a method of treating or preventing pancreatic cancer in a subject.
• METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS
  申请人：Reed John C.

  公开号：US20090118135A1

  公开（公告）日：2009-05-07

  An assay for determining compounds that inhibit activity of a BCl-2 protein, or affect conversion of Bcl-2 from an antiapoptotic to a proapoptotic form are described. In addition, compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and related Bcl-2 family members are identified.
• COMBINATION METHODS FOR TREATMENT OF DISEASE
  申请人：Rahl Peter B.

  公开号：US20130053415A1

  公开（公告）日：2013-02-28

  In some aspects, the invention provides compositions and methods of use for treating a variety of diseases. In some aspect, the compositions and methods involve combined modulation of transcriptional modulators.
• SUPER-ENHANCERS AND METHODS OF USE THEREOF
  申请人：Whitehead Institute for Biomedical Research

  公开号：US20140296218A1

  公开（公告）日：2014-10-02

  The present invention relates in some aspects to super-enhancers and related compositions, methods, and agents that are useful for modulating expression of cell type-specific genes that are required for maintenance of cell identity (e.g., embryonic stem cell identity) or maintenance of a disease state (e.g., cancer).
• US9155724B2
  申请人：——

  公开号：US9155724B2

  公开（公告）日：2015-10-13