N-ethyl-2-(4-methylphenyl)acetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-ethyl-2-(4-methylphenyl)acetamide
• 化学式: C₁₁H₁₅NO
• mdl: MFCD03637982
• 分子量: 177.24
• InChiKey: AROBVDMTHIIHFI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.363
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Nucleotide oligomer, nucleotide polymer, method for determining structure of functional substance and method for manufacturing functional substance
  申请人：Fujihara Tsuyoshi

  公开号：US20080300393A1

  公开（公告）日：2008-12-04

  A modified nucleotide n-mer (where n is an integer of 2 or more) is used which comprises a nucleoside unit with a substituent group introduced into the base, wherein the substituent group is bound to the base via a triple bond. Novel nucleotide oligomers, nucleotide polymers, and nucleosides which can be used as raw materials or intermediates in the synthesis of this nucleotide oligomer and nucleotide polymer, as well as novel techniques for structural determination and manufacture of a functional substance having high affinity for a target, are provided.

  使用改良的核苷酸n-mer（其中n是2或更多的整数）, 包括一个核苷酸单元，其中引入了一个基团取代物到碱基上，其中基团取代物通过三键与碱基结合。提供了可用作原材料或中间体用于合成此核苷酸寡聚体和核苷酸聚合物的新型核苷酸寡聚体，核苷酸聚合物和核苷，以及用于结构确定和制造具有高亲和力的靶标的功能物质的新技术。
• US7759473B2
  申请人：——

  公开号：US7759473B2

  公开（公告）日：2010-07-20
• [EN] K-RAS MODULATORS WITH A VINYL SULFONAMIDE MOIETY<br/>[FR] MODULATEURS DE K-RAS AVEC UNE FRACTION DE SULFONAMIDE DE VINYLE
  申请人：THERAS INC

  公开号：WO2019204505A2

  公开（公告）日：2019-10-24

  Provided herein are compounds comprising a vinyl sulfonamide moiety. Also provided herein are pharmaceutical compositions comprising such compounds, and methods of using such compounds and pharmaceutical compositions for inhibiting the post-translational processing of K-Ras precursors, and for treating disorders in a subject in need thereof.