C-(5,6,7,8-tetrahydro-[1]naphthyl)-methylamine | 58123-54-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: C-(5,6,7,8-tetrahydro-[1]naphthyl)-methylamine
• 英文别名: 5-Aminomethyl-tetralin；1-Aminomethyl-5.6.7.8-tetrahydro-naphthalin；(Tetralyl-(5)-methyl)-amin；(5,6,7,8-Tetrahydronaphthalen-1-yl)methanamine；5,6,7,8-tetrahydronaphthalen-1-ylmethanamine
• CAS: 58123-54-9
• 化学式: C₁₁H₁₅N
• 分子量: 161.247
• InChiKey: JPOZJSYBAPMNON-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-(4-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}piperidin-1-yl)propanoic acid 、 、 O-(7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate 、 三乙胺 、 C-(5,6,7,8-tetrahydro-[1]naphthyl)-methylamine 在 3-(4-{[(2R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}piperidin-1-yl)-N-[(5,6,7,8-tetrahydronaphthalen-1-yl)methyl]propanamide 、 氨 、 乙腈 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 18.0h， 生成 3-(4-{[(2R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}piperidin-1-yl)-N-[(5,6,7,8-tetrahydronaphthalen-1-yl)methyl]propanamide
  参考文献：
  名称：

  PHENETHANOLAMINE DERIVATIVES AS BETA2 ADRENORECEPTOR AGONISTS

  摘要：

  本发明涉及公式（I）的化合物，其制备方法，该方法的中间体以及将该化合物用于制造用于治疗ARDS，肺气肿，支气管炎，支气管扩张，COPD，哮喘和鼻炎等疾病的药物的用途。这些化合物是β2肾上腺素能受体激动剂。

  公开号：

  US20090029958A1
• 作为产物：
  描述：

  1-萘甲基胺 在 异戊醇 、 sodium 作用下， 生成 C-(5,6,7,8-tetrahydro-[1]naphthyl)-methylamine
  参考文献：
  名称：

  v.Braun, Chemische Berichte, 1922, vol. 55, p. 1705

  摘要：

  DOI：

文献信息

• Cloning and Characterization of the Promoter Region of the Human CD83 Gene
  作者：S BERCHTOLD

  DOI：10.1078/0171-2985-00128

  日期：——

  Human CD83 (hCD83) is a glycoprotein expressed predominantly on the surface of dendritic cells (DC). To get insight into the regulation of hCD83 expression, we cloned a 3037 by fragment upstream of the translation initiation codon. Deletion mutants were constructed revealing highest promoter activity in the -261 fragment containing four SP1 binding sites and one NF-kappaB element. Electrophoretic mobility shift assays demonstrated the specific interaction of NF-kappaB factors with the NF-kappaB element as well as specific binding of SP1 and SP3 to the SP1 binding site. The hCD83 promoter was inducible by TNF-alpha. This inducibility was strictly dependent on the intact NF-kappaB element.
• v. Braun, Chemische Berichte, 1922, vol. 55, p. 1704
  作者：v. Braun

  DOI：——

  日期：——
• Pyrazolo[3,4-B] Pyridine Compounds and Their Use as Pde4 Inhibitors
  申请人：Cook Caroline Mary

  公开号：US20080275078A1

  公开（公告）日：2008-11-06

  The invention provides a compound of formula (I) or a salt thereof: wherein: R 1 is C 1-3 alkyl, C 1-3 fluoroalkyl, or —CH 2 CH 2 OH; R 2 is hydrogen, methyl or C 1 fluoroalkyl; R 3 is of sub-formula (aa) or (bb): wherein Y is NCONH 2 and n 1 is 0 or 1; R 4 is H; and R 5 is a group of the sub-formula (x), (y), (y1) or (z): These compounds are PDE4 inhibitors.
• US8445481B2
  申请人：——

  公开号：US8445481B2

  公开（公告）日：2013-05-21
• [EN] PYRAZOLO[3,4-b] PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS<br/>[FR] COMPOSES DE PYRAZOLO[3,4-B] PYRIDINE ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE PDE4
  申请人：GLAXO GROUP LTD

  公开号：WO2005090354A1

  公开（公告）日：2005-09-29

  The invention provides a compound of formula (I) or a salt thereof: formula (I) wherein: R1 is C1-3alkyl, C1-3fluoroalkyl, or -CH2CH2OH; R2 is a hydrogen atom (H), methyl or C1fluoroalkyl; R3 is of sub-formula (aa) or (bb): formulae (aa), (bb) wherein Y is NCONH2 and n1 is 0 or 1; R4 is H; and R5 is a group of the sub-formula (x), (y), (y1) or (z): formulae (x), (y), (y1), (z). The invention also relates to the use of these compounds or salts in therapy as inhibitors of phosphodiesterase type IV (PDE4). For example, it relates to their use in the treatment and/or prophylaxis of inflammatory and/or allergic diseases such as chronic obstructive pulmonary disease (COPD), asthma, rheumatoid arthritis, allergic rhinitis, psoriasis or atopic dermatitis in a mammal such as a human.