4-(hydroxymethyl)-N-[(4-methylphenyl)-phenylmethyl]benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(hydroxymethyl)-N-[(4-methylphenyl)-phenylmethyl]benzamide
• 化学式: C₂₂H₂₁NO₂
• 分子量: 331.4
• InChiKey: VAONCHYTGUUIBH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Method of sensing an analyte
  申请人：The Board of Regents,The University of Texas System

  公开号：EP2230314A1

  公开（公告）日：2010-09-22

  A method of sensing an analyte in a fluid comprises: passing a fluid over a sensor array, the sensor array comprising at least one particle positioned within a cavity of a supporting member, wherein the particle comprises a polymeric resin and a receptor coupled to the polymeric resin; monitoring a spectroscopic change of the particles as the fluid is passed over the sensor array, wherein the spectroscopic change is caused by the interaction of the analyte with the particle. The receptor can be an enzyme substrate and the analyte an enzyme such as protease, nuclease or glycosidase.

  一种检测流体中分析物的方法包括：将流体通过传感器阵列，传感器阵列包括至少一个位于支撑部件空腔内的颗粒，其中颗粒包括聚合树脂和与聚合树脂耦合的受体；当流体通过传感器阵列时，监测颗粒的光谱变化，其中光谱变化是由分析物与颗粒的相互作用引起的。 受体可以是酶底物，分析物可以是酶，如蛋白酶、核酸酶或糖苷酶。
• Method and apparatus for the delivery of samples to a chemical sensor array
  申请人：——

  公开号：US20020045272A1

  公开（公告）日：2002-04-18

  A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into which a plurality of cavities may be formed. A series of chemically sensitive particles are, in one embodiment positioned within the cavities. The particles may be configured to produce a signal when a receptor coupled to the particle interacts with the analyte. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized.

  在一个实施方案中，用于快速表征多分析流体的系统包括一个光源、一个传感器阵列和一个检测器。传感器阵列由支撑件构成，支撑件上可形成多个空腔。在一个实施方案中，一系列化学敏感颗粒被放置在空腔内。当与颗粒耦合的受体与分析物相互作用时，颗粒可被配置为产生信号。利用模式识别技术，可对多分析流体中的分析物进行表征。
• Magnetic-based placement and retention of sensor elements in a sensor array
  申请人：——

  公开号：US20020160363A1

  公开（公告）日：2002-10-31

  A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into which a plurality of cavities may be formed. A series of chemically sensitive particles are, in one embodiment positioned within the cavities. The particles may be configured to produce a signal when a receptor coupled to the particle interacts with the analyte. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized.

  在一个实施方案中，用于快速表征多分析流体的系统包括一个光源、一个传感器阵列和一个检测器。传感器阵列由支撑件构成，支撑件上可形成多个空腔。在一个实施方案中，一系列化学敏感颗粒被放置在空腔内。当与颗粒耦合的受体与分析物相互作用时，颗粒可被配置为产生信号。利用模式识别技术，可对多分析流体中的分析物进行表征。
• Method and apparatus for the confinement of materials in a micromachined chemical sensor array
  申请人：——

  公开号：US20020197622A1

  公开（公告）日：2002-12-26

  A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into which a plurality of cavities may be formed. A series of chemically sensitive particles are, in one embodiment positioned within the cavities. The particles may produce a signal when a receptor coupled to the particle interacts with the analyte. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized. In an embodiment, each cavity of the plurality of cavities is designed to capture and contain a specific size particle. Flexible projections may be positioned over each of the cavities to provide retention of the particles in the cavities.

  在一个实施方案中，用于快速表征多分析流体的系统包括一个光源、一个传感器阵列和一个检测器。传感器阵列由支撑件构成，支撑件上可形成多个空腔。在一个实施方案中，一系列化学敏感颗粒被放置在空腔内。当与颗粒耦合的受体与分析物相互作用时，颗粒就会产生信号。利用模式识别技术，可对多分析流体中的分析物进行表征。在一个实施方案中，多个空腔中的每个空腔都被设计成用于捕获和容纳特定大小的颗粒。可在每个空腔上设置柔性凸起，以便将颗粒保留在空腔中。
• Method and system for collecting and transmitting chemical information
  申请人：——

  公开号：US20030064422A1

  公开（公告）日：2003-04-03

  A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into which a plurality of cavities may be formed. A series of chemically sensitive particles are, in one embodiment positioned within the cavities. The particles may be configured to produce a signal when a receptor coupled to the particle interacts with the analyte. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized.

  在一个实施方案中，用于快速表征多分析流体的系统包括一个光源、一个传感器阵列和一个检测器。传感器阵列由支撑件构成，支撑件上可形成多个空腔。在一个实施方案中，一系列化学敏感颗粒被放置在空腔内。当与颗粒耦合的受体与分析物相互作用时，颗粒可被配置为产生信号。利用模式识别技术，可对多分析流体中的分析物进行表征。