1-benzyl-15,3,5,7-tetraazatricyclo[3.3.1.1(3,7)]decane | 51081-41-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-benzyl-15,3,5,7-tetraazatricyclo[3.3.1.1(3,7)]decane
• 英文别名: 1-Benzyl-3,5,7-triaza-1-azoniatricyclo(3.3.1.13,7)decane chloride；1-benzyl-3,5,7-triaza-1-azoniatricyclo[3.3.1.13,7]decane
• CAS: 51081-41-5
• 化学式: C₁₃H₁₉N₄
• 分子量: 231.321
• InChiKey: ZEBQXLTZNFGHKI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  9.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• ORGANIC SYNTHESIS APPLICATIONS OF NON-AQUEOUS FLUORIDE SALT SOLUTIONS
  申请人：CALIFORNIA INSTITUTE OF TECHNOLOGY

  公开号：US20170057908A1

  公开（公告）日：2017-03-02

  Processes and reaction mixtures including non-aqueous solvent mixtures are presented. Non-aqueous solvent mixtures including fluoride salt and non-aqueous solvent combinations are provided that possess high fluoride ion concentrations useful for a range of applications, including organic synthesis. Further non-aqueous solvent mixtures are provided including a salt possessing a non-fluoride anion and a non-aqueous solvent that, when contacted with aqueous fluoride-containing reagents, extract fluoride ions to form non-aqueous fluoride-ion solutions possessing high fluoride-ion concentrations. The salts include an organic cation that does not possess a carbon in the β-position or does not possess a carbon in the β-position having a bound hydrogen. This salt structure facilitates its ability to be made anhydrous without decomposition. Example anhydrous fluoride salts include (2,2-dimethylpropyl)trimethylammonium fluoride and bis(2,2-dimethylpropyl)dimethylammonium fluoride. The combination of these fluoride salts with at least one fluorine-containing non-aqueous solvent (e.g., bis(2,2,2-trifluoroethyl)ether; (BTFE)) promotes solubility of the salt within the non-aqueous solvents.

  提供了包括非水溶剂混合物的过程和反应混合物。提供了包括氟化物盐和非水溶剂组合的非水溶剂混合物，其具有高氟离子浓度，可用于一系列应用，包括有机合成。还提供了包括具有非氟离子的盐和非水溶剂的非水溶剂混合物，当与含氟化物的水溶试剂接触时，提取氟离子以形成具有高氟离子浓度的非水溶性氟离子溶液。这些盐包括一个有机阳离子，该阳离子在β位不含碳或在β位含有结合氢的碳。这种盐的结构有助于使其在无水条件下不分解。例如，无水氟化物盐包括(2,2-二甲基丙基)三甲基铵氟化物和双(2,2-二甲基丙基)二甲基铵氟化物。这些氟化物盐与至少一种含氟非水溶剂（例如双(2,2,2-三氟乙基)醚；(BTFE)）的组合促进了盐在非水溶剂中的溶解度。
• STABLE LIQUID ANTIMICROBIAL SUSPENSIONS OF QUATERNARY 3,5,7-TRIAZA-1-AZONIAADAMANTANE DERIVATIVES
  申请人：THE DOW CHEMICAL COMPANY

  公开号：EP0881880A1

  公开（公告）日：1998-12-09
• NOVEL DRUG TARGETS TO OVERCOME DE NOVO DRUG-RESISTANCE IN MULTIPLE MYELOMA
  申请人：University of Florida Research Foundation, Inc.

  公开号：US20130281389A1

  公开（公告）日：2013-10-24

  Topoisomerase II alpha (topo IIα) is exported from the cell nucleus in human myeloma cells by a chromosome-maintenance protein-1 (CRM1)-dependent mechanism, resulting in topo II inhibitor resistance. The nuclear export signal (NES) of topo IIα is unique, making it a potential target for small molecule inhibitors. Small molecules NES inhibitors were identified, which inhibited binding of topo IIα to the export receptor CRM1. Inhibition was specific to topo IIα as p53 trafficking was unaffected along with topo IIα protein expression and function (decatenation). These topo IIα-specific nuclear export inhibitors may potentially lead to a new approach in circumventing drug resistance in multiple myeloma. The compounds provide a protocol for treating multiple myeloma or an oncogenic disease. Further, the topoisomerase II nuclear export signal inhibitor may be combined with a topoisomerase II inhibitor.
• NON-AQUEOUS FLUORIDE SALTS, SOLUTIONS, AND THEIR USES
  申请人：CALIFORNIA INSTITUTE OF TECHNOLOGY

  公开号：US20170062874A1

  公开（公告）日：2017-03-02

  Electrolyte solutions including at least one anhydrous fluoride salt and at least one non-aqueous solvent are presented. The fluoride salt includes an organic cation having a charge center (e.g., N, P, S, or O) that does not possess a carbon in the β-position or does not possess a carbon in the β-position having a bound hydrogen. This salt structure facilitates its ability to be made anhydrous without decomposition. Example anhydrous fluoride salts include (2,2-dimethylpropyl)trimethylammonium fluoride and bis(2,2-dimethylpropyl)dimethylammonium fluoride. Combining these fluoride salts with at least one fluorine-containing non-aqueous solvent (e.g., bis(2,2,2-trifluoroethyl)ether; (BTFE)) promotes solubility of the salt within the non-aqueous solvents. The solvent may be a mixture of at least one non-aqueous, fluorine-containing solvent and at least one other non-aqueous, fluorine or non-fluorine containing solvent (e.g., BTFE and propionitrile or dimethoxyethane). The electrolyte solutions may be employed in electrochemical cells, such as batteries, fuel cells, electrolysis systems, and capacitors.
• METHOD FOR PREPARING 5-FLUORO-1H-PYRAZOLE-4-CARBONYL FLUORIDES
  申请人：Bayer CropScience Aktiengesellschaft

  公开号：US20180118690A1

  公开（公告）日：2018-05-03

  The present invention relates to a novel method for preparing 5-fluoro-1H-pyrazole-4-carbonyl fluorides by halogen exchange reaction of 5-chloro-1H-pyrazole-4-carbonyl chlorides with alkali metal fluorides, using non-polar solvents.