2,6-bis-acetylamino-3H-pyrimidin-4-one | 40393-82-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2,6-bis-acetylamino-3H-pyrimidin-4-one
• 英文别名: 2,6-Bis-acetylamino-3H-pyrimidin-4-on；N,N'-(6-hydroxypyrimidine-2,4-diyl)diacetamide；N-(2-acetamido-6-oxo-1H-pyrimidin-4-yl)acetamide
• CAS: 40393-82-6
• 化学式: C₈H₁₀N₄O₃
• mdl: MFCD05739479
• 分子量: 210.192
• InChiKey: BZFGUPNWTQRLRB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  99.7
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  乙酸酐 、 2,4-二氨基-6-羟基嘧啶 生成 2,6-bis-acetylamino-3H-pyrimidin-4-one
  参考文献：
  名称：

  Acetylation of Some Aminopyrimidines

  摘要：

  DOI：

  10.1021/ja01652a105

文献信息

• COMPOUNDS THAT INHIBIT HUMAN DNA LIGASES AND METHODS OF TREATING CANCER
  申请人：TOMKINSON Alan E.

  公开号：US20100099683A1

  公开（公告）日：2010-04-22

  Methods for treating cancer using compounds that inhibit human DNA ligases. Methods for using compounds that inhibit human DNA ligases to provide insights into the reaction mechanisms of human DNA ligases, for example to identify the human DNA ligase involved in different DNA repair pathways. Screening methods for compounds that inhibit human DNA ligases.
• Compounds that inhibit human DNA ligases and methods of treating cancer
  申请人：University of Maryland, Baltimore

  公开号：US20140113891A1

  公开（公告）日：2014-04-24

  Methods for treating cancer using compounds that inhibit human DNA ligases. Methods for using compounds that inhibit human DNA ligases to provide insights into the reaction mechanisms of human DNA ligases, for example to identify the human DNA ligase involved in different DNA repair pathways. Screening methods for compounds that inhibit human DNA ligases.
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