6-Propan-2-ylsulfanylpyridazin-3-amine | 1319731-81-1

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 6-Propan-2-ylsulfanylpyridazin-3-amine
• 英文别名: 6-propan-2-ylsulfanylpyridazin-3-amine
• CAS: 1319731-81-1
• 化学式: C₇H₁₁N₃S
• 分子量: 169.25
• InChiKey: ZDCVBXUVEKCMDR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  77.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-Propan-2-ylsulfanylpyridazin-3-amine 、 在 碳酸氢钠 作用下， 以 乙醇 为溶剂， 反应 6.0h， 生成 2-[3-(2-Methoxyethoxy)phenyl]-3-methyl-6-propan-2-ylsulfanylimidazo[1,2-b]pyridazine
  参考文献：
  名称：

  2-Phenylimidazo[1,2-b]pyridazine derivatives highly active against Haemonchus contortus

  摘要：

  A series of 2-phenylimidazo[1,2-b]pyridazine derivatives were synthesized and evaluated for their in vitro anthelmintic activity against Haemonchus contortus. The most active compounds had in vitro LD(99) values of 30 nM, which is comparable to that of the benchmark commercial nematocide, Ivermectin. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.05.096
• 作为产物：
  描述：

  3-氨基-6-氯哒嗪 、 异丙硫醇 在 sodium hydroxide 作用下， 以 水 为溶剂， 生成 6-Propan-2-ylsulfanylpyridazin-3-amine
  参考文献：
  名称：

  2-Phenylimidazo[1,2-b]pyridazine derivatives highly active against Haemonchus contortus

  摘要：

  A series of 2-phenylimidazo[1,2-b]pyridazine derivatives were synthesized and evaluated for their in vitro anthelmintic activity against Haemonchus contortus. The most active compounds had in vitro LD(99) values of 30 nM, which is comparable to that of the benchmark commercial nematocide, Ivermectin. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.05.096

文献信息

• 2-Phenylimidazo[1,2-b]pyridazine derivatives highly active against Haemonchus contortus
  作者：Abdelselam Ali、Teresa Cablewski、Craig L. Francis、Ashit K. Ganguly、Roger M. Sargent、David G. Sawutz、Kevin N. Winzenberg

  DOI：10.1016/j.bmcl.2011.05.096

  日期：2011.7

  A series of 2-phenylimidazo[1,2-b]pyridazine derivatives were synthesized and evaluated for their in vitro anthelmintic activity against Haemonchus contortus. The most active compounds had in vitro LD(99) values of 30 nM, which is comparable to that of the benchmark commercial nematocide, Ivermectin. (C) 2011 Elsevier Ltd. All rights reserved.