2-Chloro-4-[(3-chloro-4-isocyanato-phenyl)methyl]-1-isocyanato-benzene | 20513-43-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Chloro-4-[(3-chloro-4-isocyanato-phenyl)methyl]-1-isocyanato-benzene
• 英文别名: 2-chloro-4-[(3-chloro-4-isocyanatophenyl)methyl]-1-isocyanatobenzene
• CAS: 20513-43-3
• 化学式: C₁₅H₈Cl₂N₂O₂
• 分子量: 319.1
• InChiKey: ZDYCFBQYDDRHRI-UHFFFAOYSA-N

物化性质

• 熔点：
  103-106 °C(lit.)
• 沸点：
  415.5±45.0 °C(Predicted)
• 密度：
  1.33±0.1 g/cm3(Predicted)
• 闪点：
  >230 °F
• 稳定性/保质期：
  按规定使用和贮存的不会分解，应避免接触氧化剂和潮湿环境。

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  58.9
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• COMPOSITIONS, TREATING METHODS, AND TREATED FIBROUS SUBSTRATES
  申请人：3M INNOVATIVE PROPERTIES COMPANY

  公开号：US20200378061A1

  公开（公告）日：2020-12-03

  Fluorine free compositions for treating fibrous substrates to make the fibrous substrates water repellent, method for treating the fibrous substrates with said compositions and water repellent fibrous substrates treated with said fluorine free compositions.

  不含氟的组合物用于处理纤维基底，使纤维基底具有防水性，处理纤维基底的方法以及用所述不含氟组合物处理过的防水纤维基底。
• Novel antibacterial agents
  申请人：Christensen G. Burton

  公开号：US20070134729A1

  公开（公告）日：2007-06-14

  This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands has a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, pencillinase enzyme, cephalosporinase enzyme, a transglycoslase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.

  本发明涉及一种新型多结合化合物（药剂），其为抗菌剂。该发明的多结合化合物由2-10个配体通过连接剂或连接剂共价连接而成，其中每个单价（即未连接的）配体具有与细胞壁生物合成和代谢中的酶、合成细菌细胞壁和/或细菌细胞表面的前体有结合能力，从而干扰细胞壁的合成和/或代谢。特别地，本发明的多结合化合物由2-10个配体通过连接剂或连接剂共价连接而成，其中每个配体具有能够结合青霉素结合蛋白、横向肽酶酶、横向肽酶酶底物、β-内酰胺酶、青霉素酶、头孢菌素酶、横向转移酶酶或横向转移酶酶底物的配体结构域。优选地，配体选自β-内酰胺类或糖肽类抗菌剂。
• Carbodiimide compound and compositions for rendering substrates oil and water repellent
  申请人：Audenaert A. Frans

  公开号：US20060094851A1

  公开（公告）日：2006-05-04

  The invention relates to a carbodiimide compound or mixture of carbodiimide compounds derived from a carbodiimidization reaction of at least one oligomer having at least one isocyanate group and comprising at least two repeating units deriving from one or more ethylenically unsaturated monomers.

  本发明涉及一种碳酰亚胺化合物或碳酰亚胺化合物混合物，其由至少含有至少一个异氰酸酯基团且包含至少两个重复单元的寡聚物的碳酰亚胺化反应所得，所述重复单元来自于一个或多个乙烯基不饱和单体。
• 1H-imidazo dimers
  申请人：Griesgraber W. George

  公开号：US20050026947A1

  公开（公告）日：2005-02-03

  1H-imidazo dimer compounds are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

  1H-咪唑二聚体化合物可用作免疫反应调节剂。该发明的化合物和组合物能够诱导各种细胞因子的生物合成，可用于治疗包括病毒性疾病和肿瘤性疾病在内的多种疾病。
• Beta2-Adrenergic Receptor Agonists
  申请人：Moran Edmund J.

  公开号：US20080269344A1

  公开（公告）日：2008-10-30

  Disclosed are multibinding compounds which are β2 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor.

  本发明涉及多结合化合物，其是β2肾上腺素能受体激动剂，可用于治疗和预防哮喘、支气管炎等呼吸系统疾病。它们还可用于治疗神经系统损伤和早产。