2-Methylthio-4-chloro-6-(p-methoxyanilino)-pyrimidine | 86626-98-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Methylthio-4-chloro-6-(p-methoxyanilino)-pyrimidine
• 英文别名: 6-Chloro-N-(4-methoxyphenyl)-2-(methylsulfanyl)pyrimidin-4-amine；6-chloro-N-(4-methoxyphenyl)-2-methylsulfanylpyrimidin-4-amine
• CAS: 86626-98-4
• 化学式: C₁₂H₁₂ClN₃OS
• mdl: MFCD22578165
• 分子量: 281.766
• InChiKey: DYEMLJIDNMMSED-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.166
• 拓扑面积：
  72.3
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-甲氧基苯硼酸 、 4-氨基-6-氯-2-甲硫基嘧啶 在 4-二甲氨基吡啶 、 copper diacetate 、 三乙胺 作用下， 以 氯仿 为溶剂， 反应 24.0h， 以72%的产率得到2-Methylthio-4-chloro-6-(p-methoxyanilino)-pyrimidine
  参考文献：
  名称：

  Copper-mediated coupling of aminopurines and aminopyrimidines with arylboronic acids

  摘要：

  Selective N-arylation of aminopurines and aminopyrimidines 1-3 with arylboronic acids 4-6 was explored using copper(II) acetate and the corresponding N-arylated purine and pyrimidine derivatives 7-15 were obtained in moderate to good yields. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2003.10.088

文献信息

• Novel pyrimidine and s. triazine derivatives with antilipidemic activity
  申请人：LPB Istituto Farmaceutico s.p.a.

  公开号：EP0073328A1

  公开（公告）日：1983-03-09

  Pyrimidine and s-triazine derivatives of formula (I) in which X = CH or N; Y = for example halogen, alkoxy; W = for example -S-CH2-COOH, -O-CH2-COO alkyl, -NH-CH2-CONHCH2CH2OH; Z = for example 2,3-xylidino, and methods for the preparation thereof are described. The compounds show high antiiipemic activity.

  式(I)的嘧啶和 s-三嗪衍生物 其中 X = CH 或 N；Y = 例如卤素、烷氧基；W = 例如 -S-CH2-COOH、-O-CH2-COO 烷基、-NH-CH2-CONHCH2CH2OH；Z = 例如 2,3-xylidino。这些化合物具有很高的抗血脂活性。
• US4559345A
  申请人：——

  公开号：US4559345A

  公开（公告）日：1985-12-17
• Copper-mediated coupling of aminopurines and aminopyrimidines with arylboronic acids
  作者：Ramesh A. Joshi、Pratap S. Patil、M. Muthukrishnan、C.V. Ramana、Mukund K. Gurjar

  DOI：10.1016/j.tetlet.2003.10.088

  日期：2004.1

  Selective N-arylation of aminopurines and aminopyrimidines 1-3 with arylboronic acids 4-6 was explored using copper(II) acetate and the corresponding N-arylated purine and pyrimidine derivatives 7-15 were obtained in moderate to good yields. (C) 2003 Elsevier Ltd. All rights reserved.