DL-5-(3,4-二甲氧基苄基)乙内酰脲 | 62682-18-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 中文名称: DL-5-(3,4-二甲氧基苄基)乙内酰脲
• 英文名称: DL-5-(3,4-dimethoxybenzyl)hydantoin
• 英文别名: 5-veratryl-imidazolidine-2,4-dione；5-Veratryl-imidazolidin-2,4-dion；5-(3,4-dimethoxybenzyl)hydantoin；5-[(3,4-dimethoxyphenyl)methyl]imidazolidine-2,4-dione
• CAS: 62682-18-2
• 化学式: C₁₂H₁₄N₂O₄
• 分子量: 250.254
• InChiKey: UEVGZSZRFXMFRJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  76.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  DL-5-(3,4-二甲氧基苄基)乙内酰脲 在 Flavobacterium sp. AJ-3940 作用下， 以 various solvent(s) 为溶剂， 反应 2.0h， 生成 3,4-二甲氧基-L-苯丙氨酸
  参考文献：
  名称：

  Yokozeki, Kenzo; Sano, Konosuke; Eguchi, Chikahiko, Agricultural and Biological Chemistry, 1987, vol. 51, # 3, p. 729 - 736

  摘要：

  DOI：
• 作为产物：
  描述：

  5-(3,5-Dimethoxybenzyliden)-1,3-imidazolidin-2,4-dion 在 sodium hydroxide 、 sodium amalgam 作用下， 生成 DL-5-(3,4-二甲氧基苄基)乙内酰脲
  参考文献：
  名称：

  Deulofeu; Mendivelzua, Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1933, vol. 219, p. 233,237

  摘要：

  DOI：

文献信息

• DNA encoding hydantoinase, DNA encoding N-carbamyl-L-amino acid hydrolase, recombinant DNA, transformed cell, method of producing protein, and method of producing optically active amino acid
  申请人：AJINOMOTO CO. INC

  公开号：US20030109013A1

  公开（公告）日：2003-06-12

  The present invention provides a method of producing optically active amino acids from 5-substituted hydantoin by isolating a hydantoinase gene and an N-carbamyl-L-amino acid hydrolase gene involved in an ability to convert 5-substituted hydantoin or N-carbamylamino acid into optically active amino acids from a microorganism of the genus Microbacterium having the above ability and by improving gene amplification and transcriptional and translational activities thereby preparing a recombinant wherein the amount of the desired enzymes produced is increased. The hydantoinase gene is, for example, a DNA encoding for a protein having a hydantoinase activity, which has the nucleotide sequence set forth in SEQ ID NO:1 in the Sequence. The N-carbamyl-L-amino acid hydrolase gene is, for example, a DNA encoding for a protein having an N-carbamyl-L-amino acid hydrolase activity, which has the nucleotide sequence set forth in SEQ ID NO:3 in the Sequence.

  本发明提供了一种从5-取代的海因中生产光学活性氨基酸的方法，其方法是从具有上述能力的微细菌属微生物中分离出一种参与将5-取代的海因或N-氨甲酰-L-氨基酸转化为光学活性氨基酸的能力的海因酶基因和N-氨甲酰-L-氨基酸水解酶基因，并通过改进基因扩增和转录及翻译活性从而制备出一种重组体，在该重组体中所产生的所需酶的量有所增加。例如， hydantoinaSE 基因是编码具有 hydantoinaSE 活性的蛋白质的 DNA，其核苷酸序列见序列 SEQ ID NO:1 所列。例如，N-氨基甲酰-L-氨基酸水解酶基因是编码具有 N-氨基甲酰-L-氨基酸水解酶活性的蛋白质的 DNA，其核苷酸序列见序列 SEQ ID NO:3。
• Yokozeki, Kenzo; Kubota, Koji, Agricultural and Biological Chemistry, 1987, vol. 51, # 3, p. 721 - 728
  作者：Yokozeki, Kenzo、Kubota, Koji

  DOI：——

  日期：——
• Process for the synthesis of optically active aminoacids
  申请人：MINISTERO DELL' UNIVERSITA' E DELLA RICERCA SCIENTIFICA E TECNOLOGICA

  公开号：EP0351382B1

  公开（公告）日：1994-09-21
• DNA encoding hydantoinase, DNA encoding N-carbamyl-L-amino acid hydrolase, recombinant DNA, transformed cell, method of producing protein and method of producing optically active amino acid
  申请人：Takenaka Yasuhiro

  公开号：US20060240532A1

  公开（公告）日：2006-10-26

  The present invention provides a method of producing optically active amino acids from 5-substituted hydantoin by isolating a hydantoinase gene and an N-carbamyl-L-amino acid hydrolase gene involved in an ability to convert 5-substituted hydantoin or N-carbamylamino acid into optically active amino acids from a microorganism of the genus Microbacterium having the above ability and by improving gene amplification and transcriptional and translational activities thereby preparing a recombinant wherein the amount of the desired enzymes produced is increased. The hydantoinase gene is, for example, a DNA encoding for a protein having a hydantoinase activity, which has the nucleotide sequence set forth in SEQ ID NO:1 in the Sequence. The N-carbamyl-L-amino acid hydrolase gene is, for example, a DNA encoding for a protein having an N-carbamyl-L-amino acid hydrolase activity, which has the nucleotide sequence set forth in SEQ ID NO:3 in the Sequence.
• COMPOSITION COMPRISING A UV-SCREENING AGENT, AN ANIONIC CROSSLINKED HYDROPHILIC POLYMER, A SURFACTANT HAVING AN HLB LESS THAN OR EQUAL TO 5 AND A SILICONE COPOLYMER
  申请人：L'Oreal

  公开号：US20210346249A1

  公开（公告）日：2021-11-11

  The present invention relates to a composition in the form of an oil-in-water emulsion comprising one or more UV-screening agents, one or more anionic crosslinked hydrophilic polymers, one or more surfactants having an HLB less than or equal to 5 and one or more specific silicone copolymers. The present invention also relates to a cosmetic method for treating the skin against UV radiation using said composition.