N-(4-acetamidophenyl)propanamide | 7500-98-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-acetamidophenyl)propanamide
• CAS: 7500-98-3
• 化学式: C₁₁H₁₄N₂O₂
• mdl: MFCD00027882
• 分子量: 206.24
• InChiKey: PGHIKXBWQOWBHM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.272
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] COMPOUNDS FOR TREATMENT OF CYSTIC FIBROSIS<br/>[FR] COMPOSÉS DESTINÉS AU TRAITEMENT DE LA MUCOSVISCIDOSE
  申请人：CALIFORNIA INST BIOMEDICAL RES

  公开号：WO2015003083A1

  公开（公告）日：2015-01-08

  Described herein are compounds, compositions, and methods of their use for the treatment of cystic fibrosis.

  本文描述了用于治疗囊性纤维化的化合物、组合物及其使用方法。
• Antibacterial fab i inhibitors
  申请人：Moir T. Donald

  公开号：US20070027190A1

  公开（公告）日：2007-02-01

  Disclosed herein are antibacterial compounds that inhibit fabl, a NADH-dependent enoyl [acyl carrier protein] reductase enzyme in the fatty acid biosynthesis pathway. The compounds are represented by structural formulas Ia and Ib: R1 and R2 are independently monocyclic aryl or heteroaryl groups, wherein the groups represented by R1 and R2 are optionally substituted with one or more acyclic substituents; R3 is —H or an optionally substituted C1-C8 aliphatic, C3-C8 cycloaliphatic, aryl, or heteroaryl group. X1 is a bond or a C1-C3 alkylene chain that is optionally substituted with a C1-C4 alkyl or an acidic group. X2 is an aryl, heteroaryl or C3-C8 cycloaliphatic ring, wherein the group represented by X2 is optionally substituted with triazole, tetrazole, and/or one or more acyclic substituents.
• ELASTASE INHIBITORS
  申请人：The California Institute for Biomedical Research

  公开号：US20170144998A1

  公开（公告）日：2017-05-25

  Described herein are compounds, compositions, and methods of their use for the treatment of a lung or intestinal disease.
• [EN] LUNG LOCALIZED INHIBITORS OF ALPHA(V)BETA 6<br/>[FR] INHIBITEURS D'ALPHA (V) BÊTA 6, LOCALISÉS DANS LES POUMONS
  申请人：CALIFORNIA INST BIOMEDICAL RES

  公开号：WO2015179823A2

  公开（公告）日：2015-11-26

  Described herein are compounds, compositions, and methods of their use treatment of a lung disease.
• [EN] ELASTASE INHIBITORS<br/>[FR] INHIBITEURS DE L'ÉLASTASE
  申请人：CALIFORNIA INST BIOMEDICAL RES

  公开号：WO2015200349A2

  公开（公告）日：2015-12-30

  Described herein are compounds, compositions, and methods of their use for the treatment of a lung or intestinal disease.