Methyl 2,4,5-trichlorophenyl carbonate | 7507-37-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Methyl 2,4,5-trichlorophenyl carbonate
• 英文别名: methyl (2,4,5-trichlorophenyl) carbonate
• CAS: 7507-37-1
• 化学式: C₈H₅Cl₃O₃
• 分子量: 255.5
• InChiKey: NEVIQKOGVKNCEC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Polymer
  申请人：Warwick Effect Polymers Limited

  公开号：EP2161291A2

  公开（公告）日：2010-03-10

  The application provides a method of producing a comb polymer comprising the steps of (a) Providing: (i) a plurality of monomers which are linear, branched or star-shaped, substituted or non-substituted, and have an olefinically unsaturated moiety, the olefinically unsaturated moiety being capable of undergoing addition polymerisation; (ii) an initiator compound; the initiator compound comprising a homolytically cleavable bond, (iii) a catalyst capable of catalysing the polymerisation of the monomer, and (b) Causing the catalyst to catalyse, in combination with the initiator, the polymerisation of a plurality of the monomers to produce the comb polymer catalyst and polymers obtainable by the process are also provided. Preferably, the comb polymer is capable of binding proteins and may be produced from monomers which are alkoxy polyethers, such as poly(alkyleneglycol) or polytetrahydrofuran.

  本申请提供了一种生产梳状聚合物的方法，包括以下步骤 (a) 提供：(i) 多种单体，这些单体为线型、支链型或星型、取代型或非取代型，具有烯烃不饱和基，烯烃不饱和基能够进行加成聚合；(ii) 起始剂化合物；(iii) 能催化单体聚合的催化剂，以及 (b) 催化剂与引发剂结合，催化多种单体聚合，以产生梳状聚合物催化剂和可通过该工艺获得的聚合物。梳状聚合物最好能与蛋白质结合，并可由烷氧基聚醚，如聚（亚烷基乙二醇）或聚四氢呋喃单体制得。
• LIVING RADICAL POLYMERIZATION INITIATOR COMPRISING A FUNCTIONAL GROUP CAPABLE OF REACTING WITH POLYPEPTIDES OR THE LIKE, COMB POLYMER OBTAINED THEREWITH, POLYPEPTIDE CONJUGATES AND DRUNG OBTAINED THEREFROM
  申请人：Warwick Effect Polymers Limited

  公开号：EP1646661B1

  公开（公告）日：2009-04-01
• STABILIZED PROTEIN FORMULATIONS AND USE THEREOF
  申请人：Borchard Gerrit

  公开号：US20120219538A1

  公开（公告）日：2012-08-30

  The present invention is directed to stable protein formulations, related methods and uses thereof. In particular, the invention relates to a method of stabilizing therapeutic proteins in aqueous solution.
• POLYETHYLENE GLYCOLATED SUPEROXIDE DISMUTASE MIMETICS
  申请人：Salvemini Daniela

  公开号：US20120301403A1

  公开（公告）日：2012-11-29

  Compounds and methods for utilizing compounds comprising a superoxide dismutase mimetic covalently linked to polyethylene glycol. Methods are also provided for preparing a superoxide dismutase mimetic covalently linked to a polyethylene glycol, the methods comprising reacting an activated polyethylene glycol with a superoxide dismutase mimetic, or alternatively, reacting a superoxide dismutase mimetic with an activated polyethylene glycol. A method is also provided for preventing or treating a disease or disorder in which superoxide anions are implicated, comprising administering to a subject in need thereof, a therapeutically effective amount of a compound comprising a superoxide dismutase mimetic covalently linked to a polyethylene glycol. Methods of determining the safety and efficacy of the compounds are also provided. Methods for determining the safety and efficacy can include methods in lab animals and humans.
• US4642349A
  申请人：——

  公开号：US4642349A

  公开（公告）日：1987-02-10