9-amino-6-chloropurine | 89284-30-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 9-amino-6-chloropurine
• 英文别名: 6-Chlor-9-amino-purin；9-Amino-6-chlor-purin；6-chloro-purin-9-ylamine；6-Chloropurin-9-amine
• CAS: 89284-30-0
• 化学式: C₅H₄ClN₅
• 分子量: 169.573
• InChiKey: KUWQQMCOCCZFES-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  69.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  6-chloro-9-(ethoxymethylideneamino)purine 在 溶剂黄146 作用下， 反应 0.08h， 生成 9-amino-6-chloropurine
  参考文献：
  名称：

  Harnden, Michael R.; Jarvest, Richard L., Journal of the Chemical Society. Perkin transactions I, 1991, # 9, p. 2073 - 2080

  摘要：

  DOI：

文献信息

• [EN] SUBSTITUTED 6-ANILINO-9-HETEROCYCLYLPURINE DERIVATIVES FOR INHIBITION OF PLANT STRESS<br/>[FR] DÉRIVÉS 6-ANILINO-9-HÉTÉROCYCLYLPURINE SUBSTITUÉS POUR L'INHIBITION DU STRESS DES VÉGÉTAUX
  申请人：UNIV PALACKEHO

  公开号：WO2016095881A1

  公开（公告）日：2016-06-23

  The invention relates to substituted 6-anilino-9-heterocyclylpurine derivatives of formula (I) wherein R denotes one to five substituents independently selected from the group comprising hydrogen, halogen, hydroxy, amino, alkyloxy and alkyl group, R2 is selected from the group comprising amino, halogen, hydroxy, thio, and alkylthio group, Cyc is five- or six-membered heterocyclic ring containing one oxygen atom. Said derivatives are useful for inhibition of plant stress.

  该发明涉及式（I）的取代6-苯胺基-9-杂环基嘌呤衍生物，其中R代表从氢、卤素、羟基、氨基、烷氧基和烷基组成的群体中独立选择的一个至五个取代基，R2从氨基、卤素、羟基、硫、和烷硫基组成的群体中选择，Cyc是含有一个氧原子的五元或六元杂环环。所述衍生物对于抑制植物胁迫具有用处。
• 2-Aminopurine Analogs Having HSP90-Inhibiting Activity
  申请人：Kasibhatla Rao Srinivas

  公开号：US20070185064A1

  公开（公告）日：2007-08-09

  2-Aminopurine analogs are described and demonstrated or predicted to have utility as Heat Shock Protein 90 (HSP90) inhibiting agents in the treatment and prevention of various HSP90 mediated disorders, e.g., proliferative disorders. Method of synthesis and use of such compounds are also described and claimed.

  本文描述了2-氨基嘌呤类似物，并证明或预测其在治疗和预防各种HSP90介导的疾病（如增生性疾病）中作为HSP90抑制剂具有实用价值。还描述和声称了这种化合物的合成方法和使用方法。
• BNA CLAMP METHOD
  申请人：BNA Inc.

  公开号：EP2902499A1

  公开（公告）日：2015-08-05

  Provided is a convenient and economical testing method capable of detecting a detection target nucleic acid (e.g., mutation type gene) with high sensitivity and high accuracy. A method including selectively amplifying a detection target nucleic acid by inhibiting amplification of a detection non-target nucleic acid (e.g., wild-type gene) in a test sample by using, in a nucleic acid amplification reaction, an oligonucleotide analog containing one or more kinds of one or more unit structures of various nucleoside analogs represented by the following formula (I): wherein the symbols are as defined in the DESCRIPTION, and the like, or a salt thereof, as a clamp nucleic acid, and detecting the amplified nucleic acid.

  本发明提供了一种方便、经济的检测方法，能够高灵敏度、高准确度地检测检测目标核酸（如突变型基因）。 该方法包括在核酸扩增反应中，使用一种寡核苷酸类似物，该类似物含有下式（I）代表的各种核苷类似物的一种或多种单位结构，通过抑制检测样品中检测非目标核酸（如野生型基因）的扩增，选择性地扩增检测目标核酸： 其中符号如说明书中定义的那样，或类似物或其盐作为钳夹核酸，并检测扩增的核酸。
• BNA clamp method
  申请人：BNA INC.

  公开号：US10253360B2

  公开（公告）日：2019-04-09

  The invention provides a method of selectively amplifying a detection target nucleic acid by inhibiting amplification of a detection non-target nucleic acid (e.g., wild-type gene) in a test sample by using, in a nucleic acid amplification reaction, an oligonucleotide analog containing one or more kinds of one or more unit structures of various nucleoside analogs represented by the following formula (I): wherein the symbols are as defined in the DESCRIPTION, and the like, or a salt thereof, as a clamp nucleic acid, and detecting the amplified nucleic acid.

  本发明提供了一种在核酸扩增反应中使用寡核苷酸类似物的方法，该方法通过抑制检测样品中检测非目标核酸（如野生型基因）的扩增来选择性地扩增检测目标核酸，寡核苷酸类似物含有下式（I）所代表的各种核苷类似物的一种或多种单位结构： 其中符号如说明书中定义的那样，或类似物或其盐作为钳夹核酸，并检测扩增的核酸。
• NUCLEOTIDE ANALOGS
  申请人：GILEAD SCIENCES, INC.

  公开号：EP0719273A1

  公开（公告）日：1996-07-03