1,4-dichloro-2-(2-phenylprop-2-en-1-ylsulfonyl)benzene | 1111174-18-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,4-dichloro-2-(2-phenylprop-2-en-1-ylsulfonyl)benzene
• 英文别名: 1,4-Dichloro-2-(2-phenylprop-2-en-1-ylsulfonyl)-benzene；1,4-dichloro-2-(2-phenylprop-2-enylsulfonyl)benzene
• CAS: 1111174-18-5
• 化学式: C₁₅H₁₂Cl₂O₂S
• 分子量: 327.231
• InChiKey: RJKLUHFBQRKMCU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  42.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2,5-二氯苄磺酸氯 、 2-苯基-1-丙烯 在 三乙胺盐酸盐 、 copper dichloride 作用下， 以 乙腈 为溶剂， 反应 3.0h， 以59%的产率得到1,4-dichloro-2-(2-phenylprop-2-en-1-ylsulfonyl)benzene
  参考文献：
  名称：

  Cascade synthesis of new aryl 2-phenylallyl sulfones from α-methylstyrene and aromatic mono- and bis-sulfonyl chlorides

  摘要：

  Addition products of arenesulfonyl chlorides to alpha-methylstyrene in the presence of catalytic amounts of copper(II) chloride and triethylamine hydrochloride underwent fast dehydrochlorination (according to Hofmann's rule) on heating in boiling acetonitrile to give the corresponding aryl 2-phenylallyl sulfones with high selectivity. This reaction underlay a one-pot procedure for the synthesis of new compounds that attract interest as potential biologically active substances, monomers, and cross-linking agents for polymeric materials from accessible starting compounds.

  DOI：

  10.1134/s1070428010030085

文献信息

• Cascade synthesis of new aryl 2-phenylallyl sulfones from α-methylstyrene and aromatic mono- and bis-sulfonyl chlorides
  作者：A. A. Pudikova、N. P. Gerasimova、Yu. A. Moskvichev、E. M. Alov、A. S. Danilova、O. S. Kozlova

  DOI：10.1134/s1070428010030085

  日期：2010.3

  Addition products of arenesulfonyl chlorides to alpha-methylstyrene in the presence of catalytic amounts of copper(II) chloride and triethylamine hydrochloride underwent fast dehydrochlorination (according to Hofmann's rule) on heating in boiling acetonitrile to give the corresponding aryl 2-phenylallyl sulfones with high selectivity. This reaction underlay a one-pot procedure for the synthesis of new compounds that attract interest as potential biologically active substances, monomers, and cross-linking agents for polymeric materials from accessible starting compounds.