p-hydroxybenzyl(α-hydroxy)phosphonic acid | 69796-30-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: p-hydroxybenzyl(α-hydroxy)phosphonic acid
• 英文别名: [Hydroxy-(4-hydroxyphenyl)methyl]phosphonic acid
• CAS: 69796-30-1
• 化学式: C₇H₉O₅P
• mdl: MFCD24388614
• 分子量: 204.119
• InChiKey: GTWFICRIULNPSU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.142
• 拓扑面积：
  98
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  对羟基苯甲醛 在 盐酸 、 磷酸 作用下， 反应 6.0h， 以0.65 g的产率得到p-hydroxybenzyl(α-hydroxy)phosphonic acid
  参考文献：
  名称：

  A CLEAVAGE OF SOME HYDROXYBENZYL(α-AMINO)-PHOSPHONATES IN A BASIC MEDIUM

  摘要：

  alpha -Aminobenzylphosphonic acids possessing the hydroxy groups in ortho and para positions, underwent a C-P bond cleavage during heating with aqueous NaOH solution. In the case of o- and p-hydroxy diethyl esters 1 and 3 the products of the cleavage were the corresponding aldehydes and phosphorous acid (H3PO3). The m-hydroxy derivative was not affected by a base. It has been found, that displacement of the hydroxy group by the methoxy one in the p-hydroxybenzyl(alpha -amino)phosphonic acid leads to a stability of such a compound towards a base; no a C-P bond cleavage was observed in this case.

  DOI：

  10.1080/10426509808045493

文献信息

• UTILISATION DE DENDRIMERES POUR STIMULER LA CROISSANCE CELLULAIRE
  申请人：CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

  公开号：EP1771548B1

  公开（公告）日：2012-06-27
• A CLEAVAGE OF SOME HYDROXYBENZYL(α-AMINO)-PHOSPHONATES IN A BASIC MEDIUM
  作者：Bogdan Boduszek、Agnieszka Halama

  DOI：10.1080/10426509808045493

  日期：1998.12.1

  alpha -Aminobenzylphosphonic acids possessing the hydroxy groups in ortho and para positions, underwent a C-P bond cleavage during heating with aqueous NaOH solution. In the case of o- and p-hydroxy diethyl esters 1 and 3 the products of the cleavage were the corresponding aldehydes and phosphorous acid (H3PO3). The m-hydroxy derivative was not affected by a base. It has been found, that displacement of the hydroxy group by the methoxy one in the p-hydroxybenzyl(alpha -amino)phosphonic acid leads to a stability of such a compound towards a base; no a C-P bond cleavage was observed in this case.