r-1,c-3,c-5-tris[(2-pyridylmethyl)amino]cyclohexane | 177660-40-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: r-1,c-3,c-5-tris[(2-pyridylmethyl)amino]cyclohexane
• 英文别名: N,N',N''-tris(2-pyridylmethyl)-1,3,5-cis,cis-triaminocyclohexane；Tachpyr；1-N,3-N,5-N-tris(pyridin-2-ylmethyl)cyclohexane-1,3,5-triamine
• CAS: 177660-40-1
• 化学式: C₂₄H₃₀N₆
• 分子量: 402.542
• InChiKey: ILHFCLNOTOJYHF-UHFFFAOYSA-N

物化性质

• 沸点：
  576.4±50.0 °C(Predicted)
• 密度：
  1.18±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  30
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  74.8
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  r-1,c-3,c-5-tris[(2-pyridylmethyl)amino]cyclohexane 、 氯化铜（64Cu） 在 CH₃COONH₄ 作用下， 以 水 为溶剂， 生成
  参考文献：
  名称：

  Synthesis of novel 1,3,5-cis,cis-triaminocyclohexane ligand based Cu(II) complexes as potential radiopharmaceuticals and correlation of structure and serum stability

  摘要：

  The present study describes the synthesis of Cu(II) and radioactive Cu-67.64(II) complexes with N,N',N"-tris(2-pyridylmethyl)-1,3,5-cis,cis-triaminocyclohexane (tachpyr) and a new pyridyl ring alkylated derivative, N,N',N"-tris(6-methyl-2-pyridylmethyl)1,3,5-cis,cis-triaminocyclohexane (tach-6-Me-pyr) and the investigation of their structural and solution properties as well as stability in human serum. Facile formation of both the `cold' and Cu-67.64-radiolabeled complexes, [Cu(tachpyr)](2+) and [Cu(tach-6-Me-pyr)](2+), occurs in aqueous (0.15 M NH4OAc buffer, pH 6.5) or methanolic solvent. X-ray crystallography reveals that Cu(II) is hexacoordinate in [Cu(tachpyr)](2+) while methylation at the 6-position of the pyridyl donors in tachpyr produces considerable steric hindrance. Thus one pyridyl arm of tach-6-Mepyr is rotated entirely away from copper in [Cu(tach-6-Mepyr)](2+), resulting in a highly distorted trigonal-bipyramidal coordination geometry. The solid-state structures of the complexes correlate well with their stabilities in human serum at 37 degreesC. Thus, [Cu-67(tachpyr)](2+) possesses excellent stability, being unchanged after a period of 7 days, while [Cu-67(tach-6-Mepyr)](2+) decomposes within 1 h. Tachpyr may be an excellent candidate for developing new Cu(II) radiopharmaceuticals for diagnosis and therapy. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0277-5387(01)00927-5

文献信息

• Combined use of cruciferous indoles and chelators for the treatment of papilloma virus-related conditions
  申请人：Zeligs A. Michael

  公开号：US20050063903A1

  公开（公告）日：2005-03-24

  This abstract describes eliminating the need for cutting up manufactured synthetic filament polymer yarns (for examples, nylon and Kevlar) into wool and linen lengths and respinning these again into yarns approaching wool and linen like wear properties in clothing and other textiles at significant reductions in production costs accomplished by using laser pierced holes in the plates of and adding continuous wave or pulsed sonic generators to the rear of spinneret housings through which viscous polymer fluids flow both of which produce surface irregularities in the yarns (longitudinal and circumferential ridges in valleys) in the spun continuous filaments approaching wear properties of natural wool and linen.

  该摘要描述了通过在纺丝器壳体后部添加连续波或脉冲声波发生器，并在纺丝器板上使用激光穿孔孔，消除了将制造的合成纤维聚合物纱线（例如尼龙和凯夫拉）切成羊毛和亚麻长度，并重新纺成具有羊毛和亚麻类服装和其他纺织品的纱线的需要，从而在生产成本上实现了显着的降低。这两种方法都会在连续纤维中产生表面不规则性（纵向和周向脊和谷），使其接近天然羊毛和亚麻的耐磨性质。
• METHODS AND SYSTEM FOR INTERFERING WITH VIABILITY OF BACTERIA AND RELATED COMPOUNDS AND COMPOSITIONS
  申请人：NEWMAN Dianne K.

  公开号：US20130022578A1

  公开（公告）日：2013-01-24

  Provided herein are methods and systems for interfering with viability of bacteria and related compounds and compositions.

  本文提供了干扰细菌和相关化合物和组合物生存能力的方法和系统。
• Methods and system for interfering with viability of bacteria and related compounds and compositions
  申请人：CALIFORNIA INSTITUTE OF TECHNOLOGY

  公开号：US10406211B2

  公开（公告）日：2019-09-10

  Provided herein are methods and systems for interfering with viability of bacteria and related compounds and compositions.

  本文提供了干扰细菌活力的方法和系统以及相关化合物和组合物。
• Phenazine degrading agents and related compositions, methods and systems for interfering with viability of bacteria
  申请人：CALIFORNIA INSTITUTE OF TECHNOLOGY

  公开号：US10913936B2

  公开（公告）日：2021-02-09

  Provided herein are phenazine degrading agents, methods and systems for interfering with viability of bacteria and related antimicrobial and compositions.

  本文提供了吩嗪降解剂、干扰细菌活力的方法和系统以及相关的抗菌剂和组合物。
• 2-IMINOPYRROLIDINE DERIVATES
  申请人：Eisai R&D Management Co., Ltd.

  公开号：EP1391451B1

  公开（公告）日：2011-11-23