3-Isopropyl-5-methylhydantoin | 19347-82-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 3-Isopropyl-5-methylhydantoin
• 英文别名: 3-isopropyl-5-methyl-imidazolidine-2,4-dione；5-Methyl-3-(propan-2-yl)imidazolidine-2,4-dione；5-methyl-3-propan-2-ylimidazolidine-2,4-dione
• CAS: 19347-82-1
• 化学式: C₇H₁₂N₂O₂
• 分子量: 156.184
• InChiKey: AAHSQOJZLRSWKA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• VIRAL POLYMERASE INHIBITORS
  申请人：STAMMERS Timothy

  公开号：US20110230465A1

  公开（公告）日：2011-09-22

  Compounds of formula I: wherein X, R 2 , R 3 , R 5 and R 6 are defined herein, are useful as inhibitors of the hepatitis C virus NS5B polymerase.

  式I的化合物：其中X、R2、R3、R5和R6的定义如本文所述，可用作丙型肝炎病毒NS5B聚合酶的抑制剂。
• Ferroportin inhibitors
  申请人：Vifor (International) AG

  公开号：US10738041B2

  公开（公告）日：2020-08-11

  The invention relates to novel ferroportin inhibitors of the general formula (I) pharmaceutical compositions comprising them and the use thereof as medicaments, in particular for the prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, such as particularly iron overload states such as in particular thalassemia and hemochromatosis.

  本发明涉及通式（I）的新型铁皮质素抑制剂，包括它们的药物组合物及其作为药物的用途，特别是用于预防和/或治疗由缺乏血红素或铁代谢紊乱引起的疾病，如特别是铁过载状态，尤其是地中海贫血症和血色病。
• IMIDAZOLONE DERIVATIVES FOR THE TREATMENT OF VIRAL DISEASES
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP1341766A1

  公开（公告）日：2003-09-10
• CYCLOBUTANE DERIVATIVES AS MODULATORS OF VOLTAGE-GATED POTASSIUM CHANNELS
  申请人：Autifony Therapeutics Limited

  公开号：EP3490977B1

  公开（公告）日：2020-11-25
• [EN] IMIDAZOLONE DERIVATIVES FOR THE TREATMENT OF VIRAL DISEASES<br/>[FR] DERIVES D'IMIDAZOLONE POUR LE TRAITEMENT DE MALADIES VIRALES
  申请人：HOFFMANN LA ROCHE

  公开号：WO2002042279A1

  公开（公告）日：2002-05-30

  The invention describes novel imidazolone derivatives as well as hydrolyzable esters or ethers of compounds of formula I and pharmaceutically acceptable salts thereof, a process for their manufacture, pharmaceutical compositions and the use of such compounds in medicine (formula I) wherein R?1, R2, R3¿, A and X are as defined in the description. The compounds of formula I are the human immunodeficiency virus reverse transcriptase enzyme which is involved in viral replication. Consequently the compounds of this invention may be advantageously used as therapeutic agents for HIV madiated process.