5-pentyl-imidazolidine-2,4-dione | 72587-43-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 5-pentyl-imidazolidine-2,4-dione
• 英文别名: 5-Pentyl-imidazolidin-2,4-dion；5-amylhydantoin；5-Pentyl-2,4-imidazolidinedione；5-pentylimidazolidine-2,4-dione
• CAS: 72587-43-0
• 化学式: C₈H₁₄N₂O₂
• 分子量: 170.211
• InChiKey: KEAUXAMZJMRWRO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-氨基庚酸 生成 5-pentyl-imidazolidine-2,4-dione
  参考文献：
  名称：

  Gagnon; Boivin, Canadian Journal of Research, Section B: Chemical Sciences, 1948, vol. 26, p. 503,509

  摘要：

  DOI：

文献信息

• NON-STEROIDAL ANTIANDROGENS AND SELECTIVE ANDROGEN RECEPTOR MODULATORS WITH A PYRIDYL MOIETY
  申请人：LABRIE Fernand

  公开号：US20150175576A1

  公开（公告）日：2015-06-25

  Compounds having the structure or their salts: are used to treat or reduce the likelihood of acquiring androgen-dependent diseases, such as prostate cancer, benign prostatic hyperplasia, polycystic ovarian syndrome, acne, hirsutism, seborrhea, androgenic alopecia, male baldness, muscle atrophy and weakness, sarcopenia, male hypogonadism, erectile dysfunction, female sexual dysfunction and osteoporosis. They can be formulated together with pharmaceutically acceptable diluent or carrier or otherwise made into any pharmaceutical dosage form. Combinations with other active pharmaceutical agents are also disclosed.

  具有以下结构或其盐的化合物：用于治疗或减少患雄激素依赖性疾病的可能性，如前列腺癌、良性前列腺增生、多囊卵巢综合征、痤疮、多毛症、皮脂溢、雄激素性脱发、男性秃头、肌肉萎缩和无力、肌肉质量减少、男性性腺功能减退、勃起功能障碍、女性性功能障碍和骨质疏松症。它们可以与药学上可接受的稀释剂或载体一起配制，或以任何药物剂量形式制成。还披露了与其他活性药物成分的组合。
• [EN] HISTONE DEACETYLASE (HDAC) INHIBITORS TARGETING PROSTATE TUMORS AND METHODS OF MAKING AND USING THEREOF<br/>[FR] INHIBITEURS D'HISTONE DÉSACÉTYLASE (HDAC) CIBLANT LES TUMEURS DE LA PROSTATE ET PROCÉDÉS POUR LES PRÉPARER ET LES UTILISER
  申请人：GEORGIA TECH RES INST

  公开号：WO2012050868A1

  公开（公告）日：2012-04-19

  Compounds of Formula (I), and methods of making and using thereof, are described herein; wherein AR is an aryl group, ZBG is a Zinc Binding Group, and other substituents are as defined herein. The compounds can be administered as a pharmaceutically acceptable salt, prodrug, or solvate. The compounds may be useful to treat and/or prevent hyperproliferative disorders which may include hormone sensitive and hormone refractory prostate cancers. The compounds can be formulated with a pharmaceutically acceptable carrier and, optionally one or more pharmaceutically acceptable excipients, for enteral or parenteral administration.

  本文描述了Formula (I)的化合物及其制备和使用方法；其中AR是芳基基团，ZBG是锌结合基团，其他取代基如本文所定义。这些化合物可以作为药学上可接受的盐、前药或溶剂形式进行给药。这些化合物可能有助于治疗和/或预防可以包括激素敏感和激素耐药的前列腺癌等高增殖性疾病。这些化合物可以与药学上可接受的载体以及选择性地与一个或多个药学上可接受的赋形剂配制，用于肠道或静脉注射给药。
• [EN] ARYL HYDANTOIN HETEROCYCLES AND METHODS OF USE<br/>[FR] HÉTÉROCYCLES D'ARYLHYDANTOÏNE ET LEURS PROCÉDÉS D'UTILISATION
  申请人：US HEALTH

  公开号：WO2021150603A1

  公开（公告）日：2021-07-29

  Disclosed is a compound of formula (I) in which R1, R2, R3, X1, X2, X2', X3, X4, ring A, m, n, and o are as described herein. The compound of formula (I) is useful for treating a disorder associated with androgen receptor malfunction, such as a hyperproliferative disorder, in a subject in need thereof.

  披露了一个化合物的公式（I），其中R1、R2、R3、X1、X2、X2'、X3、X4、环A、m、n和o如本文所述。公式（I）的化合物可用于治疗与雄激素受体功能障碍相关的疾病，如一个需要的患者的高增殖性疾病。
• IMIDAZOLIDINE-2,4-DIONE DERIVATIVES, AND USE THEREOF AS A CANCER DRUG
  申请人：Prevost Gregoire

  公开号：US20120083514A1

  公开（公告）日：2012-04-05

  The present application relates to novel imidazolidine-2,4-dione derivatives of the general formula (I), where R 1 , R 2 , R 3 , R 4 , X, and Y are variables. Said materials have an antiproliferative activity. They are particularly useful for treating pathological conditions and diseases, such as cancer, that are linked to abnormal cell proliferation. The invention also relates to pharmaceutical compositions containing said materials and to the use thereof for preparing a drug.

  本申请涉及一种新的咪唑啉二酮衍生物，其通式为（I），其中R1、R2、R3、R4、X和Y为变量。所述材料具有抗增殖活性。它们特别适用于治疗与异常细胞增殖相关的病理状况和疾病，如癌症。该发明还涉及含有所述材料的药物组合物，以及将其用于制备药物的用途。
• IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AND USE THEREOF AS A MEDICAMENT
  申请人：Bigg Dennis

  公开号：US20120095068A1

  公开（公告）日：2012-04-19

  The subject matter of the present application is novel imidazolidine-2,4-dione derivatives of general formula (I) in which R 1 , R 2 , R 3 and X are variables. These products have an anti-proliferative activity. They are particularly advantageous for treating pathological conditions and diseases associated with abnormal cell proliferation, such as cancers. The invention also relates to pharmaceutical compositions containing said products and to the use thereof for preparing a medicament.

  本申请的主题是一种新型咪唑啉-2,4-二酮衍生物，其通式为(I)，其中R1、R2、R3和X为变量。这些产品具有抗增殖活性。它们特别适用于治疗与异常细胞增殖相关的病理条件和疾病，如癌症。该发明还涉及含有上述产品的药物组合物以及用于制备药物的使用。