5,7-Dimethyl-3-methylthio-isothiazolo<3,4-d>pyrimidin-4,6(5H,7H)-dion | 70424-98-5

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 5,7-Dimethyl-3-methylthio-isothiazolo<3,4-d>pyrimidin-4,6(5H,7H)-dion
• 英文别名: 5,7-dimethyl-3-methylsulfanyl-7H-isothiazolo[3,4-d]pyrimidine-4,6-dione；5,7-Dimethyl-3-methylsulfanyl-[1,2]thiazolo[3,4-d]pyrimidine-4,6-dione
• CAS: 70424-98-5
• 化学式: C₈H₉N₃O₂S₂
• 分子量: 243.31
• InChiKey: GPJZEFFHXIVLDM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  107
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5,7-Dimethyl-3-methylthio-isothiazolo<3,4-d>pyrimidin-4,6(5H,7H)-dion 、 吗啉 以77%的产率得到
  参考文献：
  名称：

  OKUDA H.; TOMINAGA Y.; MATSUDA Y.; KOBOYASHI G., HETEROCYCLES, 1979, 12, NO 4, 485-488

  摘要：

  DOI：
• 作为产物：
  描述：

  methyl 6-amino-1,3-dimethyluracil-5-dithiocarboxylate 、 碘 以60%的产率得到
  参考文献：
  名称：

  OKUDA H.; TOMINAGA Y.; MATSUDA Y.; KOBOYASHI G., HETEROCYCLES, 1979, 12, NO 4, 485-488

  摘要：

  DOI：

文献信息

• ISOTHIAZOLO-PYRIMIDINEDIONE DERIVATIVES AS TRPAI MODULATORS
  申请人：Kumar Sukeerthi

  公开号：US20120010223A1

  公开（公告）日：2012-01-12

  The present invention is related to novel isothiazolo[3,4-d]pyrimidinedione and isothiazolo[5,4-d]pyrimidinedione derivatives as TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1). Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1.

  本发明涉及新型异噻唑并[3,4-d]嘧啶二酮和异噻唑并[5,4-d]嘧啶二酮衍生物作为TRPA（瞬时受体电位A亚家族）调节剂。特别地，本文所描述的化合物可用于治疗或预防由TRPA1（瞬时受体电位A亚家族，成员1）调节的疾病、状况和/或障碍。本文还提供了用于制备所述化合物的过程、用于合成的中间体、其制药组合物以及治疗或预防由TRPA1调节的疾病、状况和/或障碍的方法。
• Isothiazolo-pyrimidinedione derivatives as TRPA1 modulators
  申请人：Kumar Sukeerthi

  公开号：US08575178B2

  公开（公告）日：2013-11-05

  The present invention is related to novel isothiazolo[3,4-d]pyrimidinedione and isothiazolo[5,4-d]pyrimidinedione derivatives as TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1). Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1.

  本发明涉及新型异噻唑并[3,4-d]嘧啶二酮和异噻唑并[5,4-d]嘧啶二酮衍生物，作为TRPA（瞬时受体电位亚家族A）调节剂。特别地，所述化合物可用于治疗或预防由TRPA1（瞬时受体电位亚家族A，成员1）调节的疾病、状况和/或疾病。本文还提供了用于制备所述化合物的过程，用于合成它们的中间体，其制药组合物以及治疗或预防由TRPA1调节的疾病、状况和/或疾病的方法。
• ISOTHIAZOLO-PYRIMIDINEDIONE DERIVATIVES AS TRPA1 MODULATORS
  申请人：Glenmark Pharmaceuticals S.A.

  公开号：EP2411397B1

  公开（公告）日：2013-05-29
• US8575178B2
  申请人：——

  公开号：US8575178B2

  公开（公告）日：2013-11-05
• OKUDA H.; TOMINAGA Y.; MATSUDA Y.; KOBOYASHI G., HETEROCYCLES, 1979, 12, NO 4, 485-488
  作者：OKUDA H.、 TOMINAGA Y.、 MATSUDA Y.、 KOBOYASHI G.

  DOI：——

  日期：——