N-(2,6-difluorobenzoyl)-N’-(3,4-dichlorophenyl)urea | 35377-47-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2,6-difluorobenzoyl)-N’-(3,4-dichlorophenyl)urea
• 英文别名: N-(2,6-difluorobenzoyl)-N'-(3,4-dichlorophenyl)-urea；N-[(3,4-dichlorophenyl)carbamoyl]-2,6-difluorobenzamide
• CAS: 35377-47-0
• 化学式: C₁₄H₈Cl₂F₂N₂O₂
• 分子量: 345.133
• InChiKey: BNVZZAOYMJQJAH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Pharmaceutical compositions containing benzoyl-phenyl ureas with anti-tumour activity
  申请人：DUPHAR INTERNATIONAL RESEARCH B.V

  公开号：EP0107214A2

  公开（公告）日：1984-05-02

  A method of and composition suitable for combating tumors in mammals is disclosed, characterized in that a therapeutically effective quantity of at least one 1-benzoyl-3-phenyl ureas or a metabolite thereof, which compounds are known per se, is administered in a pharmaceutically acceptable carrier.

  本发明公开了一种适用于抗击哺乳动物肿瘤的方法和组合物，其特征在于将治疗有效量的至少一种 1-苯甲酰基-3-苯基脲或其代谢物（这些化合物本身是已知的）置于药学上可接受的载体中给药。
• Benzoyl urea derivatives having ati-tumor activity
  申请人：DUPHAR INTERNATIONAL RESEARCH B.V

  公开号：EP0193249A2

  公开（公告）日：1986-09-03

  The present invention relates to a group of new benzoyl urea derivatives of the formula having a better antitumor activity in comparison with known benzoyl urea derivatives. The compounds have been tested in several in vitro test models with different types of tumors.

  本发明涉及一组新的苯甲酰脲衍生物，其式为 与已知的苯甲酰脲衍生物相比，具有更好的抗肿瘤活性。这些化合物已在几种不同类型肿瘤的体外试验模型中进行了测试。
• Urea derivatives, their production and use
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0088343B1

  公开（公告）日：1985-07-03
• ENHANCED YIELD IN NUT BEARING PLANTS
  申请人：Arysta LifeScience North America, LLC

  公开号：US20190254281A1

  公开（公告）日：2019-08-22

  Disclosed is a method for promoting the yield of a nut-bearing plant, comprising contacting the nut-bearing plant or a part thereof with an effective amount of a compound of formula (I): wherein the variables in Formula I are defined as described herein.
• US3933908A
  申请人：——

  公开号：US3933908A

  公开（公告）日：1976-01-20