5,5-Dimethyl-2-(2-phenylethyl)-1,3-dioxane | 5445-66-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二恶烷
• 英文名称: 5,5-Dimethyl-2-(2-phenylethyl)-1,3-dioxane
• CAS: 5445-66-9
• 化学式: C₁₄H₂₀O₂
• 分子量: 220.312
• InChiKey: NONXMMADFDZEHG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5,5-Dimethyl-2-(2-phenylethyl)-1,3-dioxane 、 1,2-乙二硫醇 在 silica-supported sulfuric acid 作用下， 反应 0.07h， 以98%的产率得到2-(2-Phenylethyl)-1,3-dithiolane
  参考文献：
  名称：

  Highly efficient and chemoselective method for the thioacetalization of aldehydes and transthioacetalization of acetals and acylals catalyzed by H2SO4-silica under solvent-free conditions

  摘要：

  Chemoselective and efficient thioacetalization of a variety of aldehydes was achieved in excellent yields at room temperature using 1,2-ethanedithiol in the presence of catalytic amounts of H2SO4-silica. Thioacetals were also prepared by transthioacetalization of acylals and acetals under similar conditions.

  DOI：

  10.1007/s00706-011-0664-6
• 作为产物：
  描述：

  3-苯丙醇 、 2,2-二甲基-1,3-丙二醇 在 丙二酸 作用下， 以99 %的产率得到5,5-Dimethyl-2-(2-phenylethyl)-1,3-dioxane
  参考文献：
  名称：

  低共熔溶剂中高效且低影响的缩醛化反应

  摘要：

  天然低共熔溶剂可促进多种基材上低影响的缩醛化反应。反应介质完全循环使用，催化活性最多可达十次不减弱。

  DOI：

  10.1002/chem.202300820

文献信息

• [EN] FLUOROUS ACETYLATION<br/>[FR] ACETYLATION FLUOREE
  申请人：UNISEARCH LTD

  公开号：WO2003070714A1

  公开（公告）日：2003-08-28

  The present invention relates to a method for the synthesis of highly fluorinated compounds and to novel highly fluorinated compounds. In particular, the present invention relates to the synthesis of highly fluorinated acetals and ketals and their thio analogues and to novel highly fluorinated acetals and ketals and their thio analogues.
• Highly efficient and chemoselective method for the thioacetalization of aldehydes and transthioacetalization of acetals and acylals catalyzed by H2SO4-silica under solvent-free conditions
  作者：Seied Ali Pourmousavi、Shaghayegh Sadat Kazemi

  DOI：10.1007/s00706-011-0664-6

  日期：2012.6

  Chemoselective and efficient thioacetalization of a variety of aldehydes was achieved in excellent yields at room temperature using 1,2-ethanedithiol in the presence of catalytic amounts of H2SO4-silica. Thioacetals were also prepared by transthioacetalization of acylals and acetals under similar conditions.
• Efficient and Low‐Impact Acetalization Reactions in Deep Eutectic Solvents
  作者：Davide Arnodo、Carolina Meazzo、Salvatore Baldino、Marco Blangetti、Cristina Prandi

  DOI：10.1002/chem.202300820

  日期：2023.6.27

  Natural deep eutectic solvents promote low-impact acetalization reactions on a wide range of substrates. The reaction medium is fully recycled without weakening of the catalytic activity up to ten times.

  天然低共熔溶剂可促进多种基材上低影响的缩醛化反应。反应介质完全循环使用，催化活性最多可达十次不减弱。