2-(2-(4-Tert-butylphenoxy)acetamido)benzoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2-(4-Tert-butylphenoxy)acetamido)benzoic acid
• 英文别名: 2-[[2-(4-tert-butylphenoxy)acetyl]amino]benzoic acid
• 化学式: C₁₉H₂₁NO₄
• 分子量: 327.4
• InChiKey: RZQIBGXCHZEONC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Novel use of chemical compounds for the treatment of AIDS
  申请人：INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

  公开号：EP2062578A1

  公开（公告）日：2009-05-27

  The invention relates to the use of compound of formula (I) as medicament: in the form of a free base or of an addition salt with an acid, as well as in the form of an hydrate or of a solvate. The invention also relates to the use of such a compound of formula (I) for the preparation of a pharmaceutical composition intended for the treatment of AIDS. The invention further relates to a medicament and to pharmaceutical composition comprising a compound of formula (I).

  本发明涉及将式 (I) 化合物用作药物： 以游离碱或与酸的加成盐的形式，以及以水合物或溶液的形式。 本发明还涉及使用这种式（I）化合物制备用于治疗艾滋病的药物组合物。 本发明还涉及一种包含式（I）化合物的药物和药物组合物。
• [EN] USE OF CHEMICAL COMPOUNDS FOR THE TREATMENT OF AIDS<br/>[FR] NOUVELLE UTILISATION DE COMPOSÉS CHIMIQUES POUR LE TRAITEMENT DU SIDA
  申请人：INST NAT SANTE RECH MED

  公开号：WO2009063412A1

  公开（公告）日：2009-05-22

  The invention relates to the use of compound of formula (I) for the preparation of a pharmaceutical composition intended for the treatment of AIDS, wherein said compound of formula (I) is: in the form of a free base or of an addition salt with an acid, as well as in the form of an hydrate or of a solvate. The invention further relates to a medicament and to pharmaceutical composition comprising a compound of formula (I).
• [EN] GPR109A AGONISTS FOR THE TREATMENT OF CEREBRAL ISCHEMIA<br/>[FR] AGONISTES DE GPR109A POUR LE TRAITEMENT DE L'ISCHÉMIE CÉRÉBRALE
  申请人：UNIV RUPRECHT KARLS HEIDELBERG

  公开号：WO2011057110A1

  公开（公告）日：2011-05-12

  The present invention describes agonists for G Protein-coupled receptor 109A (GPR109A), compositions comprising the GPR109A agonists, and methods of using them. GPR109A agonists are used in methods for the treatment, prevention, and alleviation of an ischemic condition, such as cerebral ischemia.