2-((2-Oxo-2-(thiophen-2-yl)ethyl)thio)-4,6-di(thiophen-2-yl)nicotinonitrile

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 2-((2-Oxo-2-(thiophen-2-yl)ethyl)thio)-4,6-di(thiophen-2-yl)nicotinonitrile
• 英文别名: 2-(2-oxo-2-thiophen-2-ylethyl)sulfanyl-4,6-dithiophen-2-ylpyridine-3-carbonitrile
• 化学式: C₂₀H₁₂N₂OS₄
• 分子量: 424.6
• InChiKey: DCCYTKKDAZEVLY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  164
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• Compositions and methods for treatment of cancer
  申请人：Children's Hospital Medical Center

  公开号：US11026933B2

  公开（公告）日：2021-06-08

  Disclosed are methods and compositions for the treatment of a proliferative disorder characterized by increased expression of the FOXM1 gene. Exemplary disorders include adenocarcinoma, melanoma, rhabdomyosarcoma, non-small cell lung cancer (NSCLC), head and neck squamous carcinoma, hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma, colon carcinoma, basal cell carcinoma, infiltrating ductal breast carcinoma, anaplastic astrocytoma, glioblastoma, pancreatic carcinoma, gastric cancer, acute myeloid leukemia, lung cancer, liver cancer, breast cancer, prostate cancer, a brain cancer. Kits and articles of manufacture comprising compositions for such treatment are also disclosed.

  所公开的是用于治疗以 FOXM1 基因表达增加为特征的增殖性疾病的方法和组合物。示例性疾病包括腺癌、黑色素瘤、横纹肌肉瘤、非小细胞肺癌（NSCLC）、头颈部鳞状细胞癌、肝细胞癌（HCC）、肝内胆管癌、结肠癌、基底细胞癌、浸润性导管乳腺癌、无性星形细胞癌、鳞状细胞癌、基底细胞癌、浸润性乳腺导管癌、无性星形细胞瘤、胶质母细胞瘤、胰腺癌、胃癌、急性髓性白血病、肺癌、肝癌、乳腺癌、前列腺癌、脑癌。还公开了包含用于此类治疗的组合物的试剂盒和制成品。
• COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER
  申请人：Children's Hospital Medical Center

  公开号：EP3515431A1

  公开（公告）日：2019-07-31
• COMPOSITIONS AND METHODS FOR TREATMENT OF LUNG DYSFUNCTION
  申请人：Children's Hospital Medical Center

  公开号：US20170105982A1

  公开（公告）日：2017-04-20

  Described are compositions and methods for the treatment, prevention, or amelioration of a symptom of an airway disorder. In certain aspects, the airway disorder may be one characterized by one or more conditions, such as goblet cell metaplasia, lung tissue inflammation, increased airway hyperresponsiveness, mucus hyperplasia, decreased airway resistance, and increased production of pro-inflammatory cytokines. The compositions and methods may be useful for the treatment of an airway disorder such as asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), allergic disorders, pulmonary inflammatory diseases, pulmonary fibrosis, and/or interstitial lung diseases.
• US9682072B2
  申请人：——

  公开号：US9682072B2

  公开（公告）日：2017-06-20
• [EN] COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER<br/>[FR] COMPOSITIONS ET MÉTHODES DE TRAITEMENT DU CANCER
  申请人：CHILDRENS HOSPITAL MED CT

  公开号：WO2018057550A1

  公开（公告）日：2018-03-29

  Disclosed are methods and compositions for the treatment of a proliferative disorder characterized by increased expression of the FOXMl gene. Exemplary disorders include adenocarcinoma, melanoma, rhabdomyosarcoma, non-small cell lung cancer (NSCLC), head and neck squamous carcinoma, hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma, colon carcinoma, basal cell carcinoma, infiltrating ductal breast carcinoma, anaplastic astrocytoma, glioblastoma, pancreatic carcinoma, gastric cancer, acute myeloid leukemia, lung cancer, liver cancer, breast cancer, prostate cancer, a brain cancer. Kits and articles of manufacture comprising compositions for such treatment are also disclosed.