3-phenyl-N-(1,2,2,2-tetrachloroethyl)propanamide | 323591-87-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-phenyl-N-(1,2,2,2-tetrachloroethyl)propanamide
• CAS: 323591-87-3
• 化学式: C₁₁H₁₁Cl₄NO
• 分子量: 315.026
• InChiKey: PJIXFYREVDXMRH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-phenyl-N-(1,2,2,2-tetrachloroethyl)propanamide 在 氨 作用下， 以 乙醚 为溶剂， 生成 N-(1-Amino-2,2,2-trichloro-ethyl)-3-phenyl-propionamide
  参考文献：
  名称：

  Structure–activity relationship studies of salubrinal lead to its active biotinylated derivative

  摘要：

  The synthesis and structure-activity relationships (SAR) of salubrinal, a small molecule that protects cells from apoptosis induced by endoplasmic reticulum (ER) stress, are described. It is revealed that the trichloromethyl group greatly contributes to the activity. Based on the SAR results, salubrinal was converted into a biotinylated derivative which retains activity and can be used as a biological tool for target identification. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.05.120
• 作为产物：
  描述：

  3-phenyl-N-(2,2,2-trichloro-1-hydroxyethyl)propanamide 在 五氯化磷 作用下， 以 乙醚 为溶剂， 生成 3-phenyl-N-(1,2,2,2-tetrachloroethyl)propanamide
  参考文献：
  名称：

  Structure–activity relationship studies of salubrinal lead to its active biotinylated derivative

  摘要：

  The synthesis and structure-activity relationships (SAR) of salubrinal, a small molecule that protects cells from apoptosis induced by endoplasmic reticulum (ER) stress, are described. It is revealed that the trichloromethyl group greatly contributes to the activity. Based on the SAR results, salubrinal was converted into a biotinylated derivative which retains activity and can be used as a biological tool for target identification. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.05.120

文献信息

• Potassium channel openers
  申请人：——

  公开号：US20020028836A1

  公开（公告）日：2002-03-07

  Compounds of formula I: 1 are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

  公式I的化合物： 1 在治疗通过或用钾通道开放剂预防或改善的疾病中是有用的。还公开了钾通道开放组合物以及在哺乳动物中开放钾通道的方法。
• POTASSIUM CHANNEL OPENERS
  申请人：ABBOTT LABORATORIES

  公开号：EP1198456B1

  公开（公告）日：2007-09-19
• US6645968B2
  申请人：——

  公开号：US6645968B2

  公开（公告）日：2003-11-11
• [EN] POTASSIUM CHANNEL OPENERS<br/>[FR] OUVREURS DE CANAUX POTASSIQUES
  申请人：ABBOTT LAB

  公开号：WO2002062762A2

  公开（公告）日：2002-08-15

  Compounds of formula (I) are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
• Structure–activity relationship studies of salubrinal lead to its active biotinylated derivative
  作者：Kai Long、Michael Boyce、He Lin、Junying Yuan、Dawei Ma

  DOI：10.1016/j.bmcl.2005.05.120

  日期：2005.9

  The synthesis and structure-activity relationships (SAR) of salubrinal, a small molecule that protects cells from apoptosis induced by endoplasmic reticulum (ER) stress, are described. It is revealed that the trichloromethyl group greatly contributes to the activity. Based on the SAR results, salubrinal was converted into a biotinylated derivative which retains activity and can be used as a biological tool for target identification. (c) 2005 Elsevier Ltd. All rights reserved.