Ethyl-N--carbamat | 2737-83-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: Ethyl-N--carbamat
• 英文别名: N-(3-Pyridyl)-methylurethan；pyridin-3-ylmethyl-carbamic acid ethyl ester；Ethyl(pyridin-3-ylmethyl)carbamate；ethyl N-(pyridin-3-ylmethyl)carbamate
• CAS: 2737-83-9
• 化学式: C₉H₁₂N₂O₂
• mdl: MFCD01339688
• 分子量: 180.206
• InChiKey: YOTDMWXSBNBZBL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  51.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Ethyl-N--carbamat 、 亚硝酸盐 、 sodium acetate 生成 N-Nitroso-N-(3-pyridyl)methylurethan
  参考文献：
  名称：

  KAMIYA S., CHEM. AND PHARM. BULL, , 1975, 23, NO 11, 2744-2748

  摘要：

  DOI：
• 作为产物：
  描述：

  3-氨甲基吡啶 、 碘乙烷 、 DBU⁺CO₂^- 以 乙腈 为溶剂， 反应 7.5h， 以84%的产率得到Ethyl-N--carbamat
  参考文献：
  名称：

  Efficient and clean synthesis of N-alkyl carbamates by transcarboxylation and O-alkylation coupled reactions using a DBU–CO2 zwitterionic carbamic complex in aprotic polar media

  摘要：

  N-Alkyl carbamates were obtained with good to excellent yields by clean and mild transcarboxylation of several amines with the previously synthesized DBU-CO2 Complex and Subsequent O-alkylation. Transcarboxylation was found to be selective, as only carbamate was formed from 1-hydroxy-2-aminobutanol. (C) 2002 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(02)00697-4

文献信息

• Carbamate, Ester, and Ketone Compounds for Treatment of Complement Mediated Disorders
  申请人：Achillion Pharmaceuticals, Inc.

  公开号：US20150239919A1

  公开（公告）日：2015-08-27

  Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof, wherein R 12 or R 13 on the A group is a carbamate, ester, or ketone substituent (R 32 ) are provided. The inhibitors described herein target factor D and inhibit or regulate the complement cascade at an early and essential point in the alternative complement pathway, and reduce factor D's ability to modulate the classical and lectin complement pathways. The inhibitors of factor D described herein are capable of reducing the excessive activation of complement, which has been linked to certain autoimmune, inflammatory, and neurodegenerative diseases, as well as ischemia-reperfusion injury and cancer.

  本文提供了包含式I的补体因子D抑制剂的化合物、使用方法和制备方法，或其药学上可接受的盐或组合物，其中A基团上的R12或R13是一个氨基甲酸酯、酯或酮取代基（R32）。所述抑制剂靶向因子D，能够在替代补体途径的早期和关键点抑制或调节补体级联反应，并减少因子D调节经典和凝集素补体途径的能力。这些因子D抑制剂能够减少过度激活补体，这与某些自身免疫、炎症和神经退行性疾病、缺血再灌注损伤和癌症有关。
• (3-Pyridinyl)heteroalkanols and alkanoic acids and esters
  申请人：THE UPJOHN COMPANY

  公开号：EP0099685B1

  公开（公告）日：1988-09-21
• US9732103B2
  申请人：——

  公开号：US9732103B2

  公开（公告）日：2017-08-15
• Efficient and clean synthesis of N-alkyl carbamates by transcarboxylation and O-alkylation coupled reactions using a DBU–CO2 zwitterionic carbamic complex in aprotic polar media
  作者：Eduardo R Pérez、Michele Odnicki da Silva、Vanessa C Costa、Ubirajara P Rodrigues-Filho、Douglas W Franco

  DOI：10.1016/s0040-4039(02)00697-4

  日期：2002.5

  N-Alkyl carbamates were obtained with good to excellent yields by clean and mild transcarboxylation of several amines with the previously synthesized DBU-CO2 Complex and Subsequent O-alkylation. Transcarboxylation was found to be selective, as only carbamate was formed from 1-hydroxy-2-aminobutanol. (C) 2002 Published by Elsevier Science Ltd.
• KAMIYA S., CHEM. AND PHARM. BULL, <CPBT-AL>, 1975, 23, NO 11, 2744-2748
  作者：KAMIYA S.

  DOI：——

  日期：——