2,6-Bis(4-methyl-5-phenyl-4,5-dihydro-1,3-oxazol-2-yl)pyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2,6-Bis(4-methyl-5-phenyl-4,5-dihydro-1,3-oxazol-2-yl)pyridine
• 英文别名: 4-methyl-2-[6-(4-methyl-5-phenyl-4,5-dihydro-1,3-oxazol-2-yl)pyridin-2-yl]-5-phenyl-4,5-dihydro-1,3-oxazole
• 化学式: C₂₅H₂₃N₃O₂
• 分子量: 397.5
• InChiKey: WAQJMWVRZVOTCH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  56.1
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Process for preparing 5-sulfonamido-8-hydroxy-1,6-naphthyridine-7-carboxamides
  申请人：Maligres E. Peter

  公开号：US20050014780A1

  公开（公告）日：2005-01-20

  The preparation of 5-sulfonamido-8-hydroxy-1,6-naphthyridine-7-carboxamides is disclosed. A 5-halo-8-hydroxy-1,6-napthyridine-7-carboxylic acid or acid ester in which the hydroxy is derivatized with a protecting group is reacted with a sulfonamide (e.g., an alkanesulfonamide, N-alkyl alkanesulfonamide, or alkanesultam) in the presence of a copper promoter and a chelating agent, followed by deprotection of the hydroxy group, and then coupling with an amine to obtain the 5-sulfonamido-8-hydroxy-1,6-naphthyridine-7-carboxamide. Alternatively, the hydroxy-protected 5-halo-8-hydroxy-1,6-napthyridine-7-carboxylic acid (or ester) is first coupled with an amine, the resulting carboxamide reacted with a sulfonamide followed by deprotection of the hydroxy group to obtain the 5-sulfonamido-8-hydroxy-1,6-naphthyridine-7-carboxamide. The 5-sulfonamido-8-hydroxy-1,6-naphthyridine-7-carboxamides are inhibitors of HIV integrase and are useful for treating HIV infection, preventing HIV infection, delaying the onset of AIDS, and treating AIDS.

  本文公开了制备5-磺酰胺基-8-羟基-1,6-萘啶-7-羧酸酰胺的方法。首先将5-卤代-8-羟基-1,6-萘啶-7-羧酸或酸酯与保护羟基的衍生物反应，加入磺酰胺（例如，烷基磺酰胺，N-烷基磺酰胺或烷基磺酰胺）和铜催化剂以及螯合剂，去除保护羟基，然后与胺偶联，得到5-磺酰胺基-8-羟基-1,6-萘啶-7-羧酸酰胺。或者，先将保护羟基的5-卤代-8-羟基-1,6-萘啶-7-羧酸（或酯）与胺偶联，然后将产生的羧酰胺与磺酰胺反应，去除保护羟基，得到5-磺酰胺基-8-羟基-1,6-萘啶-7-羧酸酰胺。5-磺酰胺基-8-羟基-1,6-萘啶-7-羧酸酰胺是HIV整合酶的抑制剂，可用于治疗HIV感染，预防HIV感染，延缓艾滋病的发作和治疗艾滋病。
• PROCESS FOR PREPARING 5-SULFONAMIDO-8-HYDROXY-1, 6-NAPHTHYRIDINE-7-CARBOXAMIDES
  申请人：Merck & Co., Inc.

  公开号：EP1427726A1

  公开（公告）日：2004-06-16
• Nickel Containing Hydrosilylation Catalysts and Compositions Containing the Catalysts
  申请人：DOW CORNING CORPORATION

  公开号：US20140183398A1

  公开（公告）日：2014-07-03

  A composition contains (A) a hydrosilylation reaction catalyst and (B) an aliphatically unsaturated compound having an average, per molecule, of one or more aliphatically unsaturated organic groups capable of undergoing hydrosilylation reaction. The composition is capable of reacting via hydrosilylation reaction to form a reaction product, such as a silane, a gum, a gel, a rubber, or a resin. Ingredient (A) contains a metal-ligand complex that can be prepared by a method including reacting a metal precursor and a ligand,
• Hafnium Containing Hydrosilylation Catalysts and Compositions Containing the Catalysts
  申请人：Dow Corning Corporation

  公开号：US20140187783A1

  公开（公告）日：2014-07-03

  A composition contains (A) a hydrosilylation reaction catalyst and (B) an aliphatically unsaturated compound having an average, per molecule, of one or more aliphatically unsaturated organic groups capable of undergoing hydrosilylation reaction. The composition is capable of reacting via hydrosilylation reaction to form a reaction product, such as a silane, a gum, a gel, a rubber, or a resin. Ingredient (A) contains a metal-ligand complex that can be prepared by a method including reacting a metal precursor and a ligand.
• Iridium Containing Hydrosilylation Catalysts and Compositions Containing the Catalysts
  申请人：Dow Corning Corporation

  公开号：US20140206869A1

  公开（公告）日：2014-07-24

  A composition contains (A) a hydrosilylation reaction catalyst and (B) an aliphatically unsaturated compound having an average, per molecule, of one or more aliphatically unsaturated organic groups capable, of undergoing hydrosilylation reaction. The composition is capable of reacting via hydrosilylation reaction to form a reaction product, such as a silane, a gum, a gel, a rubber, or a resin. Ingredient (A) contains a metal-ligand complex that can be prepared by a method including reacting a metal precursor and a ligand.