α-(1,2,3,4-Tetrahydro-isochinolin-3-yl)-benzhydrol | 110332-80-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: α-(1,2,3,4-Tetrahydro-isochinolin-3-yl)-benzhydrol
• 英文别名: Diphenyl(1,2,3,4-tetrahydroisoquinolin-3-yl)methanol
• CAS: 110332-80-4
• 化学式: C₂₂H₂₁NO
• 分子量: 315.415
• InChiKey: RHDBEHVNWCDLDP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• NOVEL BORATE DERIVATIVES AND THEIR APPLICATIONS
  申请人：HEISE Glenn L.

  公开号：US20120289733A1

  公开（公告）日：2012-11-15

  Borates, compositions comprising chiral (cyclic and acyclic) and achiral (cyclic and acyclic) borates; chiral (cyclic and acyclic) and achiral (cyclic and acyclic) biborates; and methods for their synthesis. Additionally, a significantly improved synthetic protocol for the synthesis of wide range of boronates starting from borates or biborates and Grignard or organolithium reagents that can be used for kilo lab and commercial scale production.

  硼酸盐，包括手性（环状和非环状）和非手性（环状和非环状）硼酸盐的组合物；手性（环状和非环状）和非手性（环状和非环状）双硼酸盐；以及它们的合成方法。此外，还有一种显著改进的合成方案，用于合成从硼酸盐或双硼酸盐以及格氏试剂或有机锂试剂出发的广泛范围的硼酸酯，可用于千克级实验室和商业规模生产。
• Enantioselective reduction of ketones
  申请人：THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE

  公开号：EP0305180B1

  公开（公告）日：1995-03-22
• US4943635A
  申请人：——

  公开号：US4943635A

  公开（公告）日：1990-07-24
• US6090950A
  申请人：——

  公开号：US6090950A

  公开（公告）日：2000-07-18
• [EN] CHIRAL HYDRIDE COMPLEXES<br/>[FR] COMPLEXES D'HYDRURES CHIRAUX
  申请人：ZEELAND CHEMICALS, INC.

  公开号：WO1998007653A1

  公开（公告）日：1998-02-26

  (EN) Novel chiral boron and aluminum hydride complexes, compositions comprising the chiral hydride complexes, and methods for their synthesis and use are described. The novel chiral hydride complexes are of the formulas: MBH4-n-a(R*)n(R')a; MBH2-b(R**)(R')b; MBH(R***); MBH(R*)(R''); MAlH4-n-a(R*)n(R')a; MAlH2-b(R**)(R')b; MAlH(R***); and MAlH(R*)(R''), wherein M is Na+, Li+ or K+; each R* is independently a monodentate chiral ligand; R** is a bidentate chiral ligand; R*** is a tridentate chiral ligand; R' is a monodentate achiral ligand; R'' is a bidentate achiral ligand; n is 1-3; a is 0-2; and b is 0-1, with the proviso that n + a $m(F) 3, and with the further proviso that when R** is S-BINOL, M is not Li+.(FR) L'invention concerne de nouveaux complexes d'hydrures de bore et d'aluminium chiraux, des compositions comprenant lesdits complexes d'hydrures chiraux et des méthodes de synthèse desdits complexes et compositions. Les nouveaux complexes d'hydrures chiraux répondent aux formules: MBH4-n-a(R*)n(R')a; MBH2-b(R**) (R')b; MBH(R3***); MBH(R*)(R''); MA1H4-n-a(R*)n(R')a; MA1H2-b(R**) (R')b; MA1H(R3***) et MA1H(R*)(R''), où M est Na+, Li+ ou K+; chaque R* est indépendamment un ligand chiral monodenté; R** est un ligand chiral bidenté; R*** est un ligand chiral tridenté; R' est un ligand achiral monodenté; R'' est un ligand achiral bidenté; n est 1-3; a est 0-2 et où b est 0-1, à condition que n + a $m(F) 3 et à condition également que lorsque R** est S-BINOL, M n'est pas Li+.