phenyl-thien-3-ylmethyl chloride | 1251069-50-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: phenyl-thien-3-ylmethyl chloride
• 英文别名: phenyl-3-thienylmethyl chloride；3-[chloro(phenyl)methyl]thiophene
• CAS: 1251069-50-7
• 化学式: C₁₁H₉ClS
• 分子量: 208.711
• InChiKey: BKOSCLXNDNEENH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  28.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  phenyl-thien-3-ylmethyl chloride 、 4-hydroxy-1-[3-(2-nitrophenoxy)propyl]piperidine 生成 4-(phenyl-thien-3-ylmethoxy)-1-[3-(2-nitrophenoxy)propyl]piperidine hydrochloride
  参考文献：
  名称：

  Piperidine compounds which have useful pharmaceutical activity

  摘要：

  具有以下式(I)的吡啶衍生物：##STR1## 其中R.sup.1和R.sup.2，可以相同也可以不同，是(i)未取代的苯基或通过卤素原子、三氟甲基基团、C.sub.1-5烷基或C.sub.1-5烷氧基取代的苯基，(ii)C.sub.3-7环烷基，(iii)吡啶基或(iv)噻吩基，R.sup.3是(i)氢原子，(ii)卤素原子，(iii)C.sub.1-4烷基或(iv)C.sub.1-4烷氧基，R.sup.4是(i)氢原子或(ii)C.sub.1-4烷基，R.sup.5是(i)未取代的C.sub.1-5烷基或通过卤素原子取代的C.sub.1-5烷基，(ii)苯基或(iii)噻吩基，Z是(i)C.sub.1-6烷基，(ii)C.sub.2-6烯基或(iii)C.sub.3-6炔基或其药学上可接受的盐。根据本发明，可以提供一种无毒性的抗过敏剂和治疗缺血性心脏病的药物。

  公开号：

  US05190959A1

文献信息

• Solvent-free and catalyst-free direct alkylation of alkenes
  作者：Meng-Yao Li、Jiatong Li、Ao Gu、Xiao-Mei Nong、Shuyang Zhai、Zhu-Ying Yue、Chen-Guo Feng、Yingbin Liu、Guo-Qiang Lin

  DOI：10.1039/d3gc02685j

  日期：——

  A convenient method for synthesizing aryl-containing trisubstituted alkenes through direct alkylation of alkenes was successfully achieved under solvent-free and catalyst-free conditions. The absence of solvents was found to be crucial in initiating this sequence. Moreover, this protocol stands out due to its minimal waste production and straightforward operation. The radical capture experiment provided

  成功实现了在无溶剂、无催化剂条件下通过烯烃直接烷基化合成含芳基三取代烯烃的简便方法。发现不存在溶剂对于启动该序列至关重要。此外，该协议因其废物产生最少且操作简单而脱颖而出。自由基捕获实验为离子反应机制提供了证据。
• Diarylmethoxypiperidine derivatives
  申请人：Kaken Pharmaceutical Co., Ltd.

  公开号：EP0529365A1

  公开（公告）日：1993-03-03

  A piperidine derivative having the formula (I): wherein R¹ and R², which may be the same or different from each other, are (i) a not-substituted phenyl group or a phenyl group substituted by a halogen atom, trifluoromethyl group, a C₁₋₅ alkyl group or a C₁₋₅ alkoxyl group, (ii) a C₃₋₇ cycloalkyl group, (iii) pyridyl group or (iv) thienyl group, R³ is (i) hydrogen atom, (ii) a halogen atom, (iii) a C₁₋₄ alkyl group or (iv) a C₁₋₄ alkoxyl group, R⁴ is (i) hydrogen atom or (ii) a C₁₋₄ alkyl group. R⁵ is (i) a not-substituted C₁₋₅ alkyl group or a C₁₋₅ alkyl group substituted by a halogen atom, (ii) phenyl group or (iii) thienyl group and Z is (i) a C₁₋₆ alkylene group, (ii) a C₂₋₆ alkenylene group or (iii) a C₃₋₆ alkynylene group or a pharmacologically acceptable salt thereof. According to the present invention, an anti-allergic agent and a therapeutic agent for ischemic heart disease without toxicity can be provided.

  具有式 (I) 的哌啶衍生物： 其中 R¹ 和 R² 可以相同或互不相同，它们是 (i) 未被取代的苯基或被卤素原子、三氟甲基、C₁₋₅ 烷基或 C₁₋₅ 烷氧基取代的苯基、(ii) C₃₋₇环烷基， (iii) 吡啶基或 (iv) 噻吩基， R³ 是 (i) 氢原子， (ii) 卤素原子、(iii) C₁₋₄ 烷基或 (iv) C₁₋₄ 烷氧基，R⁴ 是 (i) 氢原子或 (ii) C₁₋₄ 烷基。R⁵ 是 (i) 未取代的 C₁₋₅ 烷基或被卤原子取代的 C₁₋₅ 烷基、(ii) 苯基或 (iii) 噻吩基，而 Z 是 (i) C₁₋₆ 亚烷基、(ii) C₂₋₆烯基或 (iii) C₃₋₆炔基或其药理学上可接受的盐。根据本发明，可以提供一种抗过敏剂和一种无毒性的缺血性心脏病治疗剂。
• US5190959A
  申请人：——

  公开号：US5190959A

  公开（公告）日：1993-03-02
• Piperidine compounds which have useful pharmaceutical activity
  申请人：Kaken Pharmaceutical Co. Ltd.

  公开号：US05190959A1

  公开（公告）日：1993-03-02

  A piperidine derivative having the formula (I): ##STR1## wherein R.sup.1 and R.sup.2, which may be the same or different from each other, are (i) a not-substituted phenyl group or a phenyl group substituted by a halogen atom, trifluoromethyl group, a C.sub.1-5 alkyl group or a C.sub.1-5 alkoxyl group, (ii) a C.sub.3-7 cycloalkyl group, (iii) pyridyl group or (iv) thienyl group, R.sup.3 is (i) hydrogen atom, (ii) a halogen atom, (iii) a C.sub.1-4 alkyl group or (iv) a C.sub.1-4 alkoxyl group, R.sup.4 is (i) hydrogen atom or (ii) a C.sub.1-4 alkyl group. R.sup.5 is (i) a not-substituted C.sub.1-5 alkyl group or a C.sub.1-5 alkyl group substituted by a halogen atom, (ii) phenyl group or (iii) thienyl group and Z is (i) a C.sub.1-6 alkylene group, (ii) a C.sub.2-6 alkenylene group or (iii) a C.sub.3-6 alkynylene group or a pharmacologically acceptable salt thereof. According to the present invention, an anti-allergic agent and a therapeutic agent for ischemic heart disease without toxicity can be provided.

  具有以下式(I)的吡啶衍生物：##STR1## 其中R.sup.1和R.sup.2，可以相同也可以不同，是(i)未取代的苯基或通过卤素原子、三氟甲基基团、C.sub.1-5烷基或C.sub.1-5烷氧基取代的苯基，(ii)C.sub.3-7环烷基，(iii)吡啶基或(iv)噻吩基，R.sup.3是(i)氢原子，(ii)卤素原子，(iii)C.sub.1-4烷基或(iv)C.sub.1-4烷氧基，R.sup.4是(i)氢原子或(ii)C.sub.1-4烷基，R.sup.5是(i)未取代的C.sub.1-5烷基或通过卤素原子取代的C.sub.1-5烷基，(ii)苯基或(iii)噻吩基，Z是(i)C.sub.1-6烷基，(ii)C.sub.2-6烯基或(iii)C.sub.3-6炔基或其药学上可接受的盐。根据本发明，可以提供一种无毒性的抗过敏剂和治疗缺血性心脏病的药物。