N'-[(4-甲氧基)硫代苯甲酰基]苯甲酸酰肼 | 1021710-12-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N'-[(4-甲氧基)硫代苯甲酰基]苯甲酸酰肼
• 英文名称: N'-[(4-methoxy)thiobenzoyl]benzoic acid hydrazide
• 英文别名: N'-(4-methoxybenzenecarbothioyl)benzohydrazide
• CAS: 1021710-12-2
• 化学式: C₁₅H₁₄N₂O₂S
• 分子量: 286.354
• InChiKey: FZJJIQGMYGFKNV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  82.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-（4-甲氧基苯基羰基硫代硫基硫代）乙酸 、 苯甲酰肼 在 sodium hydroxide 作用下， 反应 2.0h， 以52%的产率得到N'-[(4-甲氧基)硫代苯甲酰基]苯甲酸酰肼
  参考文献：
  名称：

  Bioactivity of novel transition metal complexes of N′-[(4-methoxy)thiobenzoyl]benzoic acid hydrazide

  摘要：

  Cu(II), Fe(III), and Mn(II) complexes of a novel ligand N '-[(4-methoxy)thiobenzoyl]benzoic acid hydrazide (H(2)mtbh) have been synthesized and characterized by elemental analyses, IR, UV-vis, NMR, mass, EPR and Mossbauer spectroscopy. The results suggest a square planar structure for [Cu(Hmtbh)Cl] and [Cu(mtbh)] whereas an octahedral structure for [Mn(Hmtbh)(2)] and [Fe(Hmtbh)(mtbh)]. Mn(II) and Fe(III) complexes were found to inhibit proliferation of HT29 cells. [Mn(Hmtbh)(2)] and [Fe(Hmtbh)(mtbh)] inhibited proliferation of HT29 cells with half maximal inhibition (IC50) of 8.15 +/- 0.87 and 68.1 +/- 4.8 mu M, respectively, whereas H(2)mtbh showed growth inhibition with IC50 Of 90.9 +/- 7.8 mu M and were able to inhibit NMT activity in vitro. Mn(II) and Fe(III) complexes inhibited NMT activity in a dose dependent manner with IC50 values of 20 +/- 2.2 and 60 +/- 7.2 mu M, respectively, whereas ligand (H(2)mtbh) displayed IC50 of 3.2 +/- 0.5 mM. (c) 2007 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2007.04.017

文献信息

• Bioactivity of novel transition metal complexes of N′-[(4-methoxy)thiobenzoyl]benzoic acid hydrazide
  作者：Anuraag Shrivastav、Pratibha Tripathi、Ajay K. Srivastava、Nand K. Singh、Rajendra K. Sharma

  DOI：10.1016/j.ejmech.2007.04.017

  日期：2008.3

  Cu(II), Fe(III), and Mn(II) complexes of a novel ligand N '-[(4-methoxy)thiobenzoyl]benzoic acid hydrazide (H(2)mtbh) have been synthesized and characterized by elemental analyses, IR, UV-vis, NMR, mass, EPR and Mossbauer spectroscopy. The results suggest a square planar structure for [Cu(Hmtbh)Cl] and [Cu(mtbh)] whereas an octahedral structure for [Mn(Hmtbh)(2)] and [Fe(Hmtbh)(mtbh)]. Mn(II) and Fe(III) complexes were found to inhibit proliferation of HT29 cells. [Mn(Hmtbh)(2)] and [Fe(Hmtbh)(mtbh)] inhibited proliferation of HT29 cells with half maximal inhibition (IC50) of 8.15 +/- 0.87 and 68.1 +/- 4.8 mu M, respectively, whereas H(2)mtbh showed growth inhibition with IC50 Of 90.9 +/- 7.8 mu M and were able to inhibit NMT activity in vitro. Mn(II) and Fe(III) complexes inhibited NMT activity in a dose dependent manner with IC50 values of 20 +/- 2.2 and 60 +/- 7.2 mu M, respectively, whereas ligand (H(2)mtbh) displayed IC50 of 3.2 +/- 0.5 mM. (c) 2007 Elsevier Masson SAS. All rights reserved.