(3S)-4-(2,4-dichlorophenyl)-3-methylbutan-2-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3S)-4-(2,4-dichlorophenyl)-3-methylbutan-2-one
• 化学式: C₁₁H₁₂Cl₂O
• 分子量: 231.11
• InChiKey: VPINTBXCWAZGLU-ZETCQYMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] INHIBITORS OF MINT AND USES THEREOF<br/>[FR] INHIBITEURS DE MINT ET LEURS UTILISATIONS
  申请人：UNIV COPENHAGEN

  公开号：WO2019179985A1

  公开（公告）日：2019-09-26

  The present invention relates to compounds with high affinity for the PTB domain of Mint proteins. The compound interacts with Mint, blocking the native protein-protein interactions between Mint and their natural ligands. The invention furthermore relates to the therapeutic use of these compounds in prevention and/or treatment of neurodegenerative diseases, such as cognitive diseases, for example Alzheimer's disease, as well as to the use for diagnosing Alzheimer's disease.