2-Methyl-3-nitrophenyl acetate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: 2-Methyl-3-nitrophenyl acetate
• 英文别名: (2-methyl-3-nitrophenyl) acetate
• 化学式: C9H9NO4
• mdl: MFCD00092196
• 分子量: 195.17
• InChiKey: XNCSIGUBDMDNJZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  72.1
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Process for the preparation of the 2-oxoindole derivative, Ropinirole
  申请人：Helm AG

  公开号：EP1568689A1

  公开（公告）日：2005-08-31

  The present invention relates to a process for the preparation of Ropinirole comprising the step of cyclizing a compound of the formula 15.

  本发明涉及一种制备洛匹尼罗尔的方法，包括将式15的化合物环化的步骤。
• Process for the preparation of 4-(2-dipropylaminoethyl)-1,3-dihydro-2H-indol-2-one hydrochloride
  申请人：Tarur Radhakrishna Venkatasubramanian

  公开号：US20050159605A1

  公开（公告）日：2005-07-21

  The present invention discloses a novel process and novel intermediates for the Preparation of 4-[2-(di-n-propyl amino) ethyl]-1,3-dihydro-2H-indol-2-one, commonly known as Ropinirole (I) and pharmaceutical composition comprising the same. Further the present invention also discloses a method of treatment for cardiovascular disorders and Parkinson's disease.

  本发明公开了一种新颖的工艺和新颖的中间体，用于制备4-[2-(二正丙基氨基)乙基]-1,3-二氢-2H-吲哚-2-酮，通常称为洛哌丁醇（I）以及包含相同的药物组合物。此外，本发明还公开了一种治疗心血管疾病和帕金森病的方法。
• Process for the preparation of Ropinirole
  申请人：Bertolino Andrea

  公开号：US20050192338A1

  公开（公告）日：2005-09-01

  The present invention relates to a process for the preparation of Ropinirole.

  本发明涉及一种制备罗匹尼罗的方法。
• Process for the Preparation of Indolone Derivative
  申请人：Soni Rohit Ravikant

  公开号：US20080262244A1

  公开（公告）日：2008-10-23

  A process for the preparation of 4-[2-(Di-n-propylamino)ethyl]-2,3-dihydro-1H-indol-2-one of formula (I) and its pharmaceutically acceptable salts, solvates Formula I involving new intermediates of compound of formula (A) and (B) wherein R represents (i) a halogen atom selected from fluorine, chlorine atom, bromine atom and iodine atom; (ii) lower alkanesulfonyloxy group selected from methanesulfonyloxy, ethanesulfonyloxy, isopropanesulfonyloxy, propanesulfonyloxy, butanesulfonyloxy, tert-butanesulfonyloxy, pentanesulfonyloxy, hexanesulfonyloxy; (iii) substituted or unsubstantiated arylsulfonyloxy group selected from phenylsulfonyloxy, 4-methylphenylsulfonyloxy, 2-methylphenylsulfonyloxy, 4-nitrophenylsulfonyloxy, 4-methoxyphenylsulfonyloxy, 3-chlorophenylsulfonyloxy; (iv) arylalkylsulfonyloxy group selected from benzylsulfonyloxy, 2-phenylethylsulfonyloxy, 4-phenylbutylsulfonyloxy, 4- methylbenzylsulfonyloxy, 2-methylbenzylsulfonyloxy, 4-nitrobenzylsulfonyloxy, 4-methoxybenzylsulfonyloxy, 3-chlorobenzylsulfonyloxy.

  一种制备公式（I）和其药学上可接受的盐、溶剂合物的4-[2-(二正丙基氨基)乙基]-2,3-二氢吲哚-2-酮的方法，涉及公式（A）和（B）的新中间体，其中R代表（i）从氟、氯、溴和碘中选择的卤素原子；（ii）从甲磺酰氧基、乙磺酰氧基、异丙磺酰氧基、丙磺酰氧基、丁磺酰氧基、叔丁磺酰氧基、戊磺酰氧基、己磺酰氧基中选择的低级烷基磺酰氧基；（iii）从苯基磺酰氧基、4-甲基苯基磺酰氧基、2-甲基苯基磺酰氧基、4-硝基苯基磺酰氧基、4-甲氧基苯基磺酰氧基、3-氯苯基磺酰氧基中选择的取代或未取代芳基磺酰氧基；（iv）从苄基磺酰氧基、2-苯乙基磺酰氧基、4-苯基丁基磺酰氧基、4-甲基苯基甲基磺酰氧基、2-甲基苯基磺酰氧基、4-硝基苯基磺酰氧基、4-甲氧基苯基磺酰氧基、3-氯苯基磺酰氧基中选择的芳基烷基磺酰氧基。
• PROCESS FOR THE PREPARATION OF INDOLONE DERIVATIVE
  申请人：Alembic Limited

  公开号：EP1848691B1

  公开（公告）日：2009-11-11