(11C)MC80 | 1251827-74-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: (11C)MC80
• 英文别名: 6,7-dimethoxy-2-[(6-(111C)methoxynaphthalen-2-yl)methyl]-3,4-dihydro-1H-isoquinoline
• CAS: 1251827-74-3
• 化学式: C₂₃H₂₅NO₃
• 分子量: 362.445
• InChiKey: KREIZVZORLBDNV-BJUDXGSMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  30.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  [11C]methyl iodide 、 6-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl)-naphthalen-2-ol 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.08h， 以26%的产率得到(11C)MC80
  参考文献：
  名称：

  Radiosynthesis and in vivo evaluation of [11C]MC80 for P-glycoprotein imaging

  摘要：

  P-glycoprotein (P-gp) is an ATP-dependent efflux pump protecting the body against xenobiotics. The in vitro characterized modulator 6,7-dimethoxy-2-(6-methoxy-naphthalen-2-ylmethyl)-1,2,3,4-tetrahydroisoquinoline (MC80) of the P-gp pump was labelled with C-11 and evaluated in vivo for its potential to image P-gp function and expression. Radiochemical pure (>98%) [C-11] MC80 was obtained within 25 min starting from [C-11] methyl iodide with radiochemical yield of 26%. Biodistribution studies in FVB mice demonstrated a high baseline brain uptake (7.66 +/- 1.38% ID/g at 1 min pi). Cerebral uptake was increased in mdr1a knock-out mice as well as after CsA pretreatment. Pre-administration of an excess of non-radioactive MC80 caused a reduced uptake in several target organs including brain, pancreas and intestines. The results indicate that [C-11] MC80 kinetics are modulated by P-gp. Reversesd phase-HPLC analysis of brain revealed an excellent metabolic profile (>90% intact [C-11] MC80). (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.06.097