N,N'-二异丁基-1,6-己二胺 | 16121-92-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N,N'-二异丁基-1,6-己二胺
• 中文别名: N,N’-二异丁基-1,6-己二胺；N1,n1-二异丁基-1,6-己二胺；N,N"-二异丁基-1,6-己二胺；N,N"-二异丁基-1,6-己二胺,97%
• 英文名称: 1,6-Hexanediamine, N,N'-bis(2-methylpropyl)-
• 英文别名: N,N'-bis(2-methylpropyl)hexane-1,6-diamine
• CAS: 16121-92-9
• 化学式: C₁₄H₃₂N₂
• mdl: MFCD00048339
• 分子量: 228.42
• InChiKey: LTRQCWUIJWVNNK-UHFFFAOYSA-N

物化性质

• 沸点：
  102-117 °C(Press: 2 Torr)
• 密度：
  0.8160 g/cm3(Temp: 25 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  16
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 安全说明：
  S26,S36/37/39
• 危险类别码：
  R36/37/38
• 海关编码：
  2921290000

反应信息

• 作为反应物：
  描述：

  1,2-epoxyundecane 、 N,N'-二异丁基-1,6-己二胺 以affords N,N'-(1,6-hexylene)-bis[N-isobutyl-2-hydroxyundecylamine] (I的产率得到N,N'-(1,6-hexylene)-bis[N-isobutyl 2-hydroxyundecylamine]
  参考文献：
  名称：

  Bridged-bis-hydroxyamide dicarbanilates

  摘要：

  公式为##STR1##的N，N'-桥联的[(O和/或N取代)-2-烷基-2-羟乙基胺]可通过将公式为##STR2##的环氧化物和公式为R'NH--X--NHR'的二胺缩合制备而成。由此得到的产物和二羧酰化物、酸加成盐、N，N'-二氧化物和N，N'-二铵季铵盐在体外具有抗菌活性，并可用作抗菌剂。

  公开号：

  US04140860A1

文献信息

• Novel antibacterial agents
  申请人：Christensen G. Burton

  公开号：US20070134729A1

  公开（公告）日：2007-06-14

  This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands has a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, pencillinase enzyme, cephalosporinase enzyme, a transglycoslase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.

  本发明涉及一种新型多结合化合物（药剂），其为抗菌剂。该发明的多结合化合物由2-10个配体通过连接剂或连接剂共价连接而成，其中每个单价（即未连接的）配体具有与细胞壁生物合成和代谢中的酶、合成细菌细胞壁和/或细菌细胞表面的前体有结合能力，从而干扰细胞壁的合成和/或代谢。特别地，本发明的多结合化合物由2-10个配体通过连接剂或连接剂共价连接而成，其中每个配体具有能够结合青霉素结合蛋白、横向肽酶酶、横向肽酶酶底物、β-内酰胺酶、青霉素酶、头孢菌素酶、横向转移酶酶或横向转移酶酶底物的配体结构域。优选地，配体选自β-内酰胺类或糖肽类抗菌剂。
• [EN] BIOREDUCIBLE POLY (B-AMINO ESTER)S FOR SIRNA DELIVERY<br/>[FR] POLY(ESTER B-AMINO) BIORÉDUCTIBLE POUR L'ADMINISTRATION D'ARNSI
  申请人：UNIV JOHNS HOPKINS

  公开号：WO2014066811A1

  公开（公告）日：2014-05-01

  Degradable polymers were synthesized that self-assemble with nucleic acids, proteins, hydrophobic drugs, and other small molecules to form particles that are effective for delivery into a cell, tissue and/or organism either in vitro or in vivo. The presently disclosed polymers demonstrate differential cell-type specificity, an ability to promote endosomal escape to protect the cargos from degradation and enhance delivery to the cytoplasm, and/or bioreducibility, which enables triggered intracellular drug release to be tuned to promote optimal delivery to the target cell type. The presently disclosed materials may be used to treat a wide variety of conditions or diseases, such as cancer, cardiovascular diseases, infectious diseases, and ophthalmic diseases.

  合成了可降解聚合物，可与核酸、蛋白质、疏水药物和其他小分子自组装形成颗粒，有效地输送到细胞、组织和/或生物体内，无论在体外还是体内。目前披露的聚合物表现出细胞类型特异性差异，能够促进内体逃逸以保护货物免受降解并增强输送到细胞质的能力和/或生物还原性，使触发的细胞内药物释放可调节以促进最佳输送到目标细胞类型。目前披露的材料可用于治疗各种疾病或病症，例如癌症、心血管疾病、传染病和眼科疾病。
• N,N'-bridged-bis[2-alkyl-2-hydroxyethylamines]
  申请人：Sterling Drug Inc.

  公开号：US04022833A1

  公开（公告）日：1977-05-10

  N,N'-Bridged-bis[(O and/or N-substituted)-2-alkyl-2-hydroxyethylamines] of the formula ##STR1## are prepared by condensing an epoxide of the formula ##STR2## and a diamine of the formula R'NH-X-NHR'. The products and dicarbanilates, acid-addition salts, N,N'-dioxides and N,N'-diammonium quaternary salts derived therefrom have antibacterial activity in vitro and are useful as antibacterial agents.

  式为##STR1##的N,N'-桥联双[(O和/或N取代的)2-烷基-2-羟乙胺]可通过将式为##STR2##的环氧化物和式为R'NH-X-NHR'的二胺缩合制备而成。从中得到的产物和二羧酰酸盐、酸加成盐、N,N'-二氧化物和N,N'-二铵季铵盐具有体外抗菌活性，可用作抗菌剂。
• N,N'-Bridged-bis(2-alkyl-2-hydroxyethylamine) dioxides
  申请人：Sterling Drug Inc.

  公开号：US04085144A1

  公开（公告）日：1978-04-18

  N,N'-Bridged-bis[(O and/or N-substituted)-2-alkyl-2-hydroxyethylamines] of the formula ##STR1## are prepared by condensing an epoxide of the formula ##STR2## and a diamine of the formula R'NH--X--NHR'. The products and dicarbanilates, acid-addition salts, N,N'-dioxides and N,N'-diammonium quaternary salts derived therefrom have antibacterial activity in vitro and are useful as antibacterial agents.

  公式为##STR1##的N,N'-桥联[(O和/或N取代)-2-烷基-2-羟乙胺]可通过将公式为##STR2##的环氧化物和公式为R'NH--X--NHR'的二胺缩合制备而成。由此派生的产物和二氢酰胺、酸加成盐、N,N'-二氧化物和N,N'-二铵季铵盐在体外具有抗菌活性，并可用作抗菌剂。
• N,N'-Bridged-bis[N,N'substituted-2-hydroxy alkaneammonium] salts
  申请人：Sterling Drug Inc.

  公开号：US04119668A1

  公开（公告）日：1978-10-10

  N,N'-Bridged-bis[(O and/or N-substituted)-2-alkyl-2-hydroxyethylamines] of the formula ##STR1## are prepared by condensing an epoxide of the formula ##STR2## and a diamine of the formula R'NH-X-NHR'. The products and dicarbanilates, acid-addition salts, N,N'-dioxides and N,N'-diammonium quaternary salts derived therefrom have antibacterial activity in vitro and are useful as antibacterial agents.

  公式为 ##STR1## 的N,N'-桥联的[(O和/或N取代)-2-烷基-2-羟乙胺]可通过将公式为 ##STR2## 的环氧化合物和公式为R'NH-X-NHR'的二胺进行缩合反应制备而成。由此得到的产物和二羰基酸酯、酸盐、N,N'-二氧化物和N,N'-二铵季铵盐具有体外抗菌活性，并可用作抗菌剂。