4-Benzyloxycarbonyl-6-nitro-nonanedioic acid dibenzyl ester | 263393-89-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-Benzyloxycarbonyl-6-nitro-nonanedioic acid dibenzyl ester
• 英文别名: Tribenzyl 5-nitroheptane-1,3,7-tricarboxylate
• CAS: 263393-89-1
• 化学式: C₃₁H₃₃NO₈
• 分子量: 547.605
• InChiKey: PRDRIJVQRFFMDL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  40
• 可旋转键数：
  18
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  125
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  4-Benzyloxycarbonyl-6-nitro-nonanedioic acid dibenzyl ester 在 cethyltrimethylammonium permanganate 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 生成 4-Benzyloxycarbonyl-6-oxo-nonanedioic acid dibenzyl ester
  参考文献：
  名称：

  Dual Function Glutamate-Related Ligands:  Discovery of a Novel, Potent Inhibitor of Glutamate Carboxypeptidase II Possessing mGluR3 Agonist Activity

  摘要：

  DOI：

  10.1021/jm9905559
• 作为产物：
  描述：

  dibenzyl 2-methylenepentanedioate 在 苄基三甲基氢氧化铵 作用下， 以 二氯甲烷 为溶剂， 反应 48.0h， 生成 4-Benzyloxycarbonyl-6-nitro-nonanedioic acid dibenzyl ester
  参考文献：
  名称：

  Dual Function Glutamate-Related Ligands:  Discovery of a Novel, Potent Inhibitor of Glutamate Carboxypeptidase II Possessing mGluR3 Agonist Activity

  摘要：

  DOI：

  10.1021/jm9905559

文献信息

• LIGANDS FOR METABOTROPIC GLUTAMATE RECEPTORS AND INHIBITORS OF NAALADASE
  申请人：Kozikowski Alan P.

  公开号：US20080176821A1

  公开（公告）日：2008-07-24

  The present invention relates to novel compounds and formulations thereof which compounds are ligands, e.g., agonists or antagonists, for a metabotropic glutamate receptor or a NAALADase enzyme or both. The present invention also relates to methods of modulating the activity of a metabotropic glutamate receptor or a NAALADase enzyme or both, e.g., in a subject in need thereof, using a compound or formulation of the present invention. The present invention also relates to methods of treating a subject suffering from a chronic or acute disease, malady or condition due at least in part to an abnormality in the activity of an endogenous metabotropic glutamate receptor or a NAALADase enzyme or both, using a compound or formulation of the present invention.
• US7381745B2
  申请人：——

  公开号：US7381745B2

  公开（公告）日：2008-06-03
• Dual Function Glutamate-Related Ligands:  Discovery of a Novel, Potent Inhibitor of Glutamate Carboxypeptidase II Possessing mGluR3 Agonist Activity
  作者：Fajun Nan、Tomasz Bzdega、Sergey Pshenichkin、Jarda T. Wroblewski、Barbara Wroblewska、Joseph H. Neale、Alan P. Kozikowski

  DOI：10.1021/jm9905559

  日期：2000.3.1