2-[(2E)-3-(4-Tert-butylphenyl)-2-methylprop-2-EN-1-ylidene]propanedinitrile

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[(2E)-3-(4-Tert-butylphenyl)-2-methylprop-2-EN-1-ylidene]propanedinitrile
• 英文别名: 2-[3-(4-tert-butylphenyl)-2-methylprop-2-enylidene]propanedinitrile
• 化学式: C₁₇H₁₈N₂
• 分子量: 250.34
• InChiKey: OIASAVWSBWJWBR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  47.6
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] (AZIRIDINYL HYDROXY)-FUNCTIONAL ORGANIC COMPOUNDS<br/>[FR] COMPOSÉS ORGANIQUES FONCTIONNELS D'(AZIRIDINYLE HYDROXY)
  申请人：COVESTRO NETHERLANDS BV

  公开号：WO2021148558A1

  公开（公告）日：2021-07-29

  The invention relates to particular (aziridinyl hydroxy)-functional organic component. The invention further relates to liquid compositions comprising said (aziridinyl hydroxy)-functional organic component. The invention further relates to coating compositions comprising said (aziridinyl hydroxy)-functional organic component. The invention further relates to liquid coating compositions comprising said (aziridinyl hydroxy)-functional organic component. The invention further relates to a kit-of-parts comprising in one of its parts a liquid composition comprising a particular (aziridinyl hydroxy)-functional organic component. The invention further relates to cured forms of said liquid compositions, coating compositions, and liquid coating compositions. The invention further relates to articles comprising the (aziridinyl hydroxy)-functional organic component and/or the liquid compositions and/or the liquid coating compositions and/or their cured forms. The invention further relates to various uses of the (aziridinyl hydroxy)- functional organic component and/or said liquid compositions, and/or said liquid coating compositions, and/or said kit-of-parts and/or said cured forms.

  该发明涉及特定的（环氧环丙基羟基）-功能有机组分。该发明还涉及包含所述（环氧环丙基羟基）-功能有机组分的液体组合物。该发明还涉及包含所述（环氧环丙基羟基）-功能有机组分的涂料组合物。该发明还涉及包含所述（环氧环丙基羟基）-功能有机组分的液体涂料组合物。该发明还涉及一种部件中包含液体组合物的套件，所述液体组合物包含特定的（环氧环丙基羟基）-功能有机组分。该发明还涉及所述液体组合物、涂料组合物和液体涂料组合物的固化形式。该发明还涉及包含（环氧环丙基羟基）-功能有机组分和/或液体组合物和/或液体涂料组合物和/或其固化形式的物品。该发明还涉及（环氧环丙基羟基）-功能有机组分和/或所述液体组合物和/或所述液体涂料组合物和/或所述套件和/或所述固化形式的各种用途。
• [EN] THIOL-PROTECTED AMINO ACID DERIVATIVES AND USES THEREOF<br/>[FR] DÉRIVÉS D'ACIDE AMINÉ À PROTECTION THIOL ET LEURS UTILISATIONS
  申请人：JOHANNES GUTENBERG UNIVERSITÄT MAINZ

  公开号：WO2015169908A1

  公开（公告）日：2015-11-12

  The present invention relates to thiol-protected amino acid derivatives of formulae (I) and (II), peptides and block-copolymers containing the compounds and methods for preparing same. The present invention also relates to core-shell particles comprising such thiol-protected block-copolymers and compositions thereof.

  本发明涉及式(I)和(II)的巯基保护氨基酸衍生物，含有这些化合物的肽和嵌段共聚物，以及制备它们的方法。本发明还涉及包含这种巯基保护嵌段共聚物的核-壳粒子及其组合物。
• MULTI-AZIRIDINE COMPOUND
  申请人：DSM IP ASSETS B.V.

  公开号：US20210332031A1

  公开（公告）日：2021-10-28

  The present invention relates to a multi-aziridine compound having: a) from 2 to 6 of the following structural units (A): (A) whereby R′, R″, R 1 , R 2 , R 3 and R 4 are as defined herein m is an integer from 1 to 6; b) one or more linking chains wherein each one of these linking chains links two of the structural units A; and c) a molecular weight in the range from 600 Daltons to 5000 Daltons. The multi-aziridine compound can be used for example for crosslinking of for example carboxylic acid functional polymers dissolved and/or dispersed in an aqueous medium.

  本发明涉及一种多环氮丙烷化合物，其具有：a) 2至6个以下结构单元（A）：（A），其中R′、R″、R1、R2、R3和R4如本文所定义，m为1至6的整数；b) 一个或多个连接链，其中每个连接链连接两个结构单元A；以及c) 分子量在600道尔顿至5000道尔顿范围内。该多环氮丙烷化合物可用于例如交联溶解和/或分散在水性介质中的羧酸官能聚合物。
• [EN] HYDROPHOBICALLY MODIFIED ANTISENSE OLIGONUCLEOTIDES COMPRISING A TRIPLE ALKYL CHAIN<br/>[FR] OLIGONUCLÉOTIDES ANTI-SENS MODIFIÉES PAR HYDROPHOBIE COMPRENANT UNE CHAÎNE ALKYLE TRIPLE
  申请人：INST NAT SANTE RECH MED

  公开号：WO2014195432A1

  公开（公告）日：2014-12-11

  The present invention concerns an oligonucleotide modified by substitution at the 3' or the 5' end by a moiety comprising at least three saturated or unsaturated, linear or branched hydrocarbon chains comprising from 2 to 30 carbon atoms, and the use therefore as a medicament, in particular for use for treating cancer.

  本发明涉及一种寡核苷酸，其在3'端或5'端被至少包含三条饱和或不饱和、线性或支链烃链的基团取代，并且作为药物的用途，特别用于治疗癌症。
• [EN] INTRACELLULAR DELIVERY AND MITOCHONDRIAL TARGETING BY FLUORINATION<br/>[FR] ADMINISTRATION INTRACELLULAIRE ET CIBLAGE MITOCHONDRIAL PAR FLUORATION
  申请人：TEXAS A & M UNIV SYS

  公开号：WO2020198646A1

  公开（公告）日：2020-10-01

  In an embodiment, the present disclosure relates to a targeting platform that includes a targeted delivery system including an agent. In some embodiments, the targeted delivery system is modified by fluorination. In some embodiments, the targeted delivery system is electrically charge neutral. In a further embodiment, the present disclosure relates to a method that includes fluorinating a targeting compound with a fluorinating reagent and loading an agent with the fluorinated targeting compound to thereby form a micelle. In an additional embodiment, the present disclosure relates to a targeting platform that includes a fluorinated polymeric system including an agent. In another embodiment, the present disclosure relates to a method that includes fluorinating a targeting compound with a fluorinating reagent and loading an agent with the fluorinated targeting compound to thereby form a micelle. Additionally, the method can include administering the fluorinated targeting compound to a subject.

  在一种实施例中，本公开涉及一种包括代理的定位平台，其中包括一个定向传递系统。在某些实施例中，定向传递系统通过氟化进行修改。在某些实施例中，定向传递系统具有电荷中性。在另一种实施例中，本公开涉及一种方法，其中包括使用氟化试剂氟化定向化合物，并使用氟化定向化合物装载代理以形成胶束。在另一种实施例中，本公开涉及一种包括含有代理的氟化聚合物系统的定位平台。此外，该方法可以包括将氟化定向化合物用于治疗对象。