3,3-Difluoro-4-(3-fluorophenyl)-1-phenylazetidin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: 3,3-Difluoro-4-(3-fluorophenyl)-1-phenylazetidin-2-one
• 化学式: C₁₅H₁₀F₃NO
• 分子量: 277.24
• InChiKey: AVTMXJVZVOQWRL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• METHODS RELATED TO OPIOID THERAPEUTICS
  申请人：The Scripps Research Institute

  公开号：US20210338680A1

  公开（公告）日：2021-11-04

  The present invention provides methods for modulating opioid receptor mediated analgesic effect, e.g., promoting or enhancing analgesia in subjects in need of pain relief. Also provided in the invention are methods for ameliorating or suppressing withdrawal symptoms in subjects with chronic opioid use. These methods of the invention entail administering to the subjects in need of treatment a therapeutically effective amount of a GPR139 antagonist compound. The invention further provides methods for identifying novel compounds that can be useful for modulating opioid receptor mediated analgesic effect.