N-((1S,2R)-2-azido-1,2-diphenylethyl)-4-methylbenzenesulfonamide | 438590-75-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: N-((1S,2R)-2-azido-1,2-diphenylethyl)-4-methylbenzenesulfonamide
• 英文别名: N-[(1S,2R)-2-azido-1,2-diphenylethyl]-4-methylbenzenesulfonamide
• CAS: 438590-75-1
• 化学式: C₂₁H₂₀N₄O₂S
• 分子量: 392.481
• InChiKey: WYHXMDBPOKYLOM-RTWAWAEBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  68.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-((1S,2R)-2-azido-1,2-diphenylethyl)-4-methylbenzenesulfonamide 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 为溶剂， 以86%的产率得到N-((1S,2R)-2-amino-1,2-diphenylethyl)-4-methylbenzenesulfonamide
  参考文献：
  名称：

  The importance of 1,2-anti-disubstitution in monotosylated diamine ligands for ruthenium(II)-catalysed asymmetric transfer hydrogenation

  摘要：

  The synthesis and applications to transfer hydrogenation of three derivatives of the popular TsDPEN are described. The results clearly demonstrate the importance of both disubstitution and the anti arrangement of substituents on this ligand. An explanation for the significance of these results is forwarded. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2004.05.025
• 作为产物：
  描述：

  N-((1S,2R)-2-hydroxy-1,2-diphenylethyl)-4-methylbenzene sulfonamide 在 sodium azide 、 三乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 生成 N-((1S,2R)-2-azido-1,2-diphenylethyl)-4-methylbenzenesulfonamide
  参考文献：
  名称：

  The importance of 1,2-anti-disubstitution in monotosylated diamine ligands for ruthenium(II)-catalysed asymmetric transfer hydrogenation

  摘要：

  The synthesis and applications to transfer hydrogenation of three derivatives of the popular TsDPEN are described. The results clearly demonstrate the importance of both disubstitution and the anti arrangement of substituents on this ligand. An explanation for the significance of these results is forwarded. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2004.05.025

文献信息

• The importance of 1,2-anti-disubstitution in monotosylated diamine ligands for ruthenium(II)-catalysed asymmetric transfer hydrogenation
  作者：Aidan Hayes、Guy Clarkson、Martin Wills

  DOI：10.1016/j.tetasy.2004.05.025

  日期：2004.7

  The synthesis and applications to transfer hydrogenation of three derivatives of the popular TsDPEN are described. The results clearly demonstrate the importance of both disubstitution and the anti arrangement of substituents on this ligand. An explanation for the significance of these results is forwarded. (C) 2004 Elsevier Ltd. All rights reserved.