Trimethylolpropane benzoate diacrylate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Trimethylolpropane benzoate diacrylate
• 英文别名: 2,2-bis(prop-2-enoyloxymethyl)butyl benzoate
• 化学式: C₁₉H₂₂O₆
• 分子量: 346.4
• InChiKey: FNYSXXARASJZSL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  25
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  78.9
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• NANOCOMPOSITES OF GOLD AND POLYMERS
  申请人：THE JOHNS HOPKINS UNIVERSITY

  公开号：US20140294909A1

  公开（公告）日：2014-10-02

  A layer-by-layer (LbL) system, which alternately ionically complexes anionic AuNPs to two unique cationic polymers (disulfide-reducible and hydrolytically degradable) and two anionic nucleic acids, is disclosed.

  本文介绍了一种逐层（LbL）系统，该系统交替离子复合两种独特的阳离子聚合物（二硫键可还原和水解降解）和两种阴离子核酸到阴离子AuNPs上。
• POLYMERIC NANOPARTICLES FOR INTRACELLULAR PROTEIN DELIVERY
  申请人：The Johns Hopkins University

  公开号：US20220395589A1

  公开（公告）日：2022-12-15

  Cationic polymers having one or more anionic ligand end groups, including a new class of carboxylated branched poly(beta-amino ester)s that can self-assemble into nanoparticles for efficient intracellular delivery of different biomolecules, including a variety of proteins is disclosed.

  本发明涉及具有一个或多个阴离子配体末端基团的阳离子聚合物，包括一种新型的羧化支链聚β-氨基酯，可自组装成纳米粒子，以实现不同生物分子的高效胞内传递，包括各种蛋白质。
• Synthetic surfaces for culturing stem cell derived oligodendrocyte progenitor cells
  申请人：Asterias Biotherapeutics, Inc.

  公开号：US10221390B2

  公开（公告）日：2019-03-05

  Synthetic surfaces suitable for culturing stem cell derived oligodendrocyte progenitor cells contain acrylate polymers formed from one or more acrylate monomers. The acrylate surfaces, in many cases, are suitable for culturing stem cell derived oligodendrocyte progenitor cells in chemically defined media.

  适用于培养干细胞衍生的少突胶质祖细胞的合成表面含有由一种或多种丙烯酸酯单体形成的丙烯酸酯聚合物。 在许多情况下，丙烯酸酯表面适合在化学定义的培养基中培养干细胞衍生的少突胶质祖细胞。
• Biomimetic peptide and biodegradable delivery platform for the treatment of angiogenesis- and lymphangiogenesis-dependent diseases
  申请人：THE JOHNS HOPKINS UNIVERSITY

  公开号：US10774112B2

  公开（公告）日：2020-09-15

  Mimetic peptides having anti-angiogenic and anti-tumorigenic properties and methods of their use for treating cancer, ocular diseases, such as age-related macular degeneration, and other-angiogenesis-dependent diseases are disclosed. More particularly, an isolated peptide comprising the amino acid sequence LRRFSTAPFAFIDINDVINF, which exhibits anti-angiogenic activity in endothelial cell proliferation, migration, adhesion, and tube formation assays, anti-migratory activity in human breast cancer cells in vitro, anti-angiogenic and anti-tumorigenic activity in vivo in breast cancer xenograft models, and age-related macular degeneration models is disclosed. The isolate peptide also exhibits anti-lymphangiogenic and directly anti-tumorigenic properties.

  本发明公开了具有抗血管生成和抗肿瘤特性的模拟肽及其用于治疗癌症、眼部疾病（如老年性黄斑变性）和其他依赖血管生成的疾病的方法。更具体地说，公开了一种由氨基酸序列 LRRFSTAPFAFIDINDVINF 组成的分离肽，它在内皮细胞增殖、迁移、粘附和管形成试验中表现出抗血管生成活性，在体外人乳腺癌细胞中表现出抗迁移活性，在体内乳腺癌异种移植模型和老年性黄斑变性模型中表现出抗血管生成和抗肿瘤活性。分离肽还具有抗淋巴管生成和直接抗肿瘤的特性。
• Peptide/particle delivery systems
  申请人：THE JOHNS HOPKINS UNIVERSITY

  公开号：US10786463B2

  公开（公告）日：2020-09-29

  Polymeric nanoparticles, microparticles, and gels for delivering cargo, e.g., a therapeutic agent, such as a peptide, to a target, e.g., a cell, and their use for treating diseases, including angiogenesis-dependent diseases, such as age-related macular degeneration and cancer, are disclosed. Methods for formulating, stabilizing, and administering single peptides or combinations of peptides via polymeric particle and gel delivery systems also are disclosed.

  本发明公开了用于向靶标（如细胞）输送货物（如肽等治疗剂）的聚合物纳米颗粒、微颗粒和凝胶，以及它们在治疗疾病（包括血管生成依赖性疾病，如老年性黄斑变性和癌症）中的用途。 还公开了通过聚合物颗粒和凝胶给药系统配制、稳定和给药单一肽或肽组合的方法。