N-(5,6,7,8-Tetrahydro-naphthalen-1-yl)-methanesulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: N-(5,6,7,8-Tetrahydro-naphthalen-1-yl)-methanesulfonamide
• 英文别名: N-(5,6,7,8-tetrahydronaphthalen-1-yl)methanesulfonamide
• 化学式: C₁₁H₁₅NO₂S
• mdl: MFCD20142707
• 分子量: 225.312
• InChiKey: QRVJTWCSHBVLBF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.454
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-氨基四氢化萘 、 1H-benzotriazol-1-yl methanesulfonate 以 N,N-二甲基甲酰胺 为溶剂， 反应 48.0h， 以60%的产率得到N-(5,6,7,8-Tetrahydro-naphthalen-1-yl)-methanesulfonamide
  参考文献：
  名称：

  1H-Benzotriazol-1-yl methanesulfonate: A regioselective N-mesylating reagent

  摘要：

  1H-Benzotriazol-1-yl methanesulfonate has been found to be an effective reagent in selective mesylation for differentiating amino groups from one another. In a molecule with both primary and secondary amino groups, mesylation only occurred at the primary amino group. When a compound contains both amino and hydroxy groups, the reagent selectively mesylated at the amino groups. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)80034-8

文献信息

• 1H-Benzotriazol-1-yl methanesulfonate: A regioselective N-mesylating reagent
  作者：Sun Young Kim、Nack-Do Sung、Joong-Kwon Choi、Sung Soo Kim

  DOI：10.1016/s0040-4039(98)80034-8

  日期：1999.1

  1H-Benzotriazol-1-yl methanesulfonate has been found to be an effective reagent in selective mesylation for differentiating amino groups from one another. In a molecule with both primary and secondary amino groups, mesylation only occurred at the primary amino group. When a compound contains both amino and hydroxy groups, the reagent selectively mesylated at the amino groups. (C) 1998 Elsevier Science Ltd. All rights reserved.