[2-[(9,10-dioxoanthracen-2-yl)amino]-2-oxoethyl] 4-(1H-indol-3-yl)butanoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: [2-[(9,10-dioxoanthracen-2-yl)amino]-2-oxoethyl] 4-(1H-indol-3-yl)butanoate
• 化学式: C₂₈H₂₂N₂O₅
• 分子量: 466.5
• InChiKey: QUIZIMCPJXCWOX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  35
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  105
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• METHODS OF TREATING CANCERS WITH GPR132 INHIBITORS
  申请人：The Board of Regents of the University of Texas System

  公开号：US20210095293A1

  公开（公告）日：2021-04-01

  The current disclosure describes therapeutic methods for treating cancer by inhibition of G protein-coupled receptor 132 (GPR132) in the tumor microenvironment. Aspects of the disclosure relate to a method for reducing and/or inhibiting cancer cell proliferation or tumor growth in a subject having cancerous cells or tumor growth, the method comprising administering an effective amount of an agent that inhibits GPR132 to the subject.