3-Isobutyryloxypyridine | 138376-64-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-Isobutyryloxypyridine
• 英文别名: Pyridin-3-yl 2-methylpropanoate
• CAS: 138376-64-4
• 化学式: C₉H₁₁NO₂
• 分子量: 165.192
• InChiKey: LQIRTLOXBSHLOH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  苏合香醇 、 3-Isobutyryloxypyridine 生成 (R)-1-phenylethyl isobutyrate
  参考文献：
  名称：

  Utility of Acyloxypyridines and Acylazoles for the Lipasecatalyzed Enantioselective Acylation of 1-Phenylethanol

  摘要：

  研究发现，3-乙酰氧基吡啶和4-乙酰基-1,2,4-三唑在脂酶P（来自荧光假单胞菌）的催化下，能以立体选择性方式与（RS）-1-苯乙醇反应，生成高纯度的（R）-1-苯乙基羧酸酯。

  DOI：

  10.1246/cl.1991.1989

文献信息

• HETEROCYCLIC COMPOUNDS AS ADENOSINE ANTAGONISTS
  申请人：GiraFpharma LLC

  公开号：US20190023666A1

  公开（公告）日：2019-01-24

  Aminopyrazine compounds as modulators of an adenosine receptor are provided. The compounds may find use as therapeutic agents for the treatment of diseases mediated through a G-protein-coupled receptor signaling pathway and may find particular use in oncology.

  提供了氨基吡嗪化合物作为腺苷受体的调节剂。这些化合物可能作为治疗经由G蛋白偶联受体信号通路介导的疾病的治疗剂，并且可能在肿瘤学中发挥特定作用。
• Heterocyclic compounds as adenosine antagonists
  申请人：NUVATION BIO INC.

  公开号：US11028058B2

  公开（公告）日：2021-06-08

  Aminopyrazine compounds as modulators of an adenosine receptor are provided. The compounds may find use as therapeutic agents for the treatment of diseases mediated through a G-protein-coupled receptor signaling pathway and may find particular use in oncology.

  提供了作为腺苷受体调节剂的氨基吡嗪化合物。这些化合物可用作治疗剂，用于治疗通过 G 蛋白偶联受体信号通路介导的疾病，尤其可用于肿瘤学。
• ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE
  申请人：MERCK & CO., INC.

  公开号：EP1067929A1

  公开（公告）日：2001-01-17
• OXAZOLIDINONE DERIVATIVE HAVING 7-MEMBERED HETERO RING
  申请人：Suzuki Hideyuki

  公开号：US20100256355A1

  公开（公告）日：2010-10-07

  The present invention provides a novel oxazolidinone derivative of the formula (I): wherein Ring A is (A-1) a 7-membered monocyclic heterocycle containing three N atoms; (A-2) a 7-membered monocyclic heterocycle containing two N atoms and one O atom; or (A-3) a 7-membered monocyclic heterocycle containing two N atoms and one S atom, SO or SO 2 , wherein said monocyclic heterocycle is optionally substituted, optionally unsaturated and optionally fused with another ring; X 1 is a single bond, or a heteroatom-containing group selected from the group consisting of —O—, —S—, —NR 2 —, —CO—, —CS—, —CONR 3 —, —NR 4 CO—, —SO 2 NR 5 —, and —NR 6 SO 2 —, wherein R 2 , R 3 , R 4 , R 5 and R 6 are independently hydrogen or lower alkyl, or lower alkylene or lower alkenylene each optionally interrupted by said heteroatom-containing group; Ring B is optionally substituted carbocycle or optionally substituted heterocycle; and R 1 is hydrogen, or an organic residue which is able to bind to the 5 -position of the oxazolidinone ring in oxazolidinone antimicrobial agents, pharmaceutically acceptable salts and solvates thereof which are useful as an antibacterial agent.
• US8163763B2
  申请人：——

  公开号：US8163763B2

  公开（公告）日：2012-04-24